Seroatlas · Human Serome Atlas

ASDURF

ASNSD1 upstream open reading frame protein

Also known as: ASURF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: L0R819
Gene: ASDURF
Ensembl: ENSG00000286053
Chromosome: 2
Canonical length: 96 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in protein stabilization. Part of RPAP3/R2TP/prefoldin-like complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>L0R819|ASDURF
     1  MPSRGTRPED SSVLIPTDNS TPHKEDLSSK IKEQKIVVDE LSNLKKNRKV YRQQQNSNIF
    61  FLADRTEMLS ESKNILDELK KEYQEIENLD KTKIKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASDURF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

lymph node: 5.7 nTPM
gallbladder: 4.6 nTPM
thyroid gland: 4.1 nTPM
retina: 3.5 nTPM
tonsil: 3.5 nTPM
cerebral cortex: 3.3 nTPM

Single-cell type

neutrophil progenitors: 0.1 nCPM
syncytiotrophoblasts: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

NK-cell: 3.2 nTPM
non-classical monocyte: 2.5 nTPM
T-reg: 1.8 nTPM
naive CD4 T-cell: 1.6 nTPM
plasmacytoid DC: 1.6 nTPM
naive CD8 T-cell: 1.4 nTPM

Brain region

cerebral cortex: 9.4 nTPM
pons: 2.7 nTPM
amygdala: 2.5 nTPM
medulla oblongata: 2.3 nTPM
cerebellum: 2.1 nTPM
white matter: 2.1 nTPM

OntologyGO

Biological processes

protein stabilization

Cellular components

Protein domainsUniProt · Pfam · InterPro

Prefoldin
ASNSD1 upstream open reading frame protein
ASNSD1 upstream open reading frame protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASDURF as an antibody target. Whether an autoantibody or antibody against ASDURF could matter depends on whether native ASDURF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASDURF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASDURF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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