Cation efflux
IPR002524
Definition
This family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence. Cation Diffusion Facilitator (CDF) transporter proteins, including SLC30A, which is involved in zinc transport, and FieF, which is associated with metal detoxification are involved in the transport of divalent metal cations across cellular membranes. They facilitate the efflux or sequestration of metals such as zinc, cadmium, iron, manganese, and cobalt, contributing to metal homeostasis and detoxification. These proteins often function as antiporters, coupling the transport of metal ions with protons or other ions. They play crucial roles in various biological processes, including maintaining cellular metal ion balance, protecting cells from metal toxicity, and regulating metal ion concentrations in specific cellular compartments [[cite:PMID:9696746], [cite:PMID:8829543]].
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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