Seroatlas · Human Serome Atlas

SLC30A10

Calcium/manganese antiporter SLC30A10

Also known as: DKFZp547M236, ZnT-10, ZNT10_HUMAN, ZNT8, ZRC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6XR72
Gene
SLC30A10
Ensembl
ENSG00000196660
Chromosome
1
Canonical length
485 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q6XR72|SLC30A10
     1  MGRYSGKTCR LLFMLVLTVA FFVAELVSGY LGNSIALLSD SFNMLSDLIS LCVGLSAGYI
    61  ARRPTRGFSA TYGYARAEVV GALSNAVFLT ALCFTIFVEA VLRLARPERI DDPELVLIVG
   121  VLGLLVNVVG LLIFQDCAAW FACCLRGRSR RLQQRQQLAE GCVPGAFGGP QGAEDPRRAA
   181  DPTAPGSDSA VTLRGTSVER KREKGATVFA NVAGDSFNTQ NEPEDMMKKE KKSEALNIRG
   241  VLLHVMGDAL GSVVVVITAI IFYVLPLKSE DPCNWQCYID PSLTVLMVII ILSSAFPLIK
   301  ETAAILLQMV PKGVNMEELM SKLSAVPGIS SVHEVHIWEL VSGKIIATLH IKYPKDRGYQ
   361  DASTKIREIF HHAGIHNVTI QFENVDLKEP LEQKDLLLLC NSPCISKGCA KQLCCPPGAL
   421  PLAHVNGCAE HNGGPSLDTY GSDGLSRRDA REVAIEVSLD SCLSDHGQSL NKTQEDQCYV
   481  NRTHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • liver: 44 nTPM
  • duodenum: 23 nTPM
  • small intestine: 8.6 nTPM
  • basal ganglia: 4.9 nTPM
  • rectum: 4.9 nTPM
  • cerebral cortex: 4.7 nTPM

Single-cell type

  • hepatocytes: 237 nCPM
  • plasma cells: 219 nCPM
  • colonocytes: 159 nCPM
  • choroid plexus epithelial cells: 134 nCPM
  • bergmann glia: 133 nCPM
  • enterocytes: 130 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • neutrophil: 0.3 nTPM
  • NK-cell: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM

Brain region

  • choroid plexus: 9.6 nTPM
  • hypothalamus: 7.6 nTPM
  • basal ganglia: 6.8 nTPM
  • midbrain: 6.8 nTPM
  • cerebral cortex: 6.4 nTPM
  • amygdala: 5.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC30A10.

Disease | AllUniProt

Conditions SLC30A10 is implicated in, by any mechanism.

  • Hypermanganesemia with dystonia 1 (HMNDYT1) MIM:613280

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 311 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypermanganesemia with dystonia, polycythemia, and cirrhosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
0.98
gnomAD missense Z
1.58
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A10 as an antibody target. Whether an autoantibody or antibody against SLC30A10 could matter depends on whether native SLC30A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A10 is annotated at the cell surface, where native SLC30A10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC30A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC30A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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