Seroatlas · Human Serome Atlas

SLC30A2

Proton-coupled zinc antiporter SLC30A2

Also known as: ZNT2, ZNT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRI3
Gene
SLC30A2
Ensembl
ENSG00000158014
Chromosome
1
Canonical length
372 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q9BRI3|SLC30A2
     1  MEAKEKQHLL DARPAIRSYT GSLWQEGAGW IPLPRPGLDL QAIELAAQSN HHCHAQKGPD
    61  SHCDPKKGKA QRQLYVASAI CLLFMIGEVV GGYLAHSLAV MTDAAHLLTD FASMLISLFS
   121  LWMSSRPATK TMNFGWQRAE ILGALVSVLS IWVVTGVLVY LAVERLISGD YEIDGGTMLI
   181  TSGCAVAVNI IMGLTLHQSG HGHSHGTTNQ QEENPSVRAA FIHVIGDFMQ SMGVLVAAYI
   241  LYFKPEYKYV DPICTFVFSI LVLGTTLTIL RDVILVLMEG TPKGVDFTAV RDLLLSVEGV
   301  EALHSLHIWA LTVAQPVLSV HIAIAQNTDA QAVLKTASSR LQGKFHFHTV TIQIEDYSED
   361  MKDCQACQGP SD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 79 nTPM
  • thyroid gland: 19 nTPM
  • kidney: 16 nTPM
  • gallbladder: 6.2 nTPM
  • heart muscle: 4.9 nTPM
  • placenta: 4.2 nTPM

Single-cell type

  • endometrial luminal cells: 122 nCPM
  • syncytiotrophoblasts: 117 nCPM
  • breast lactating cells: 104 nCPM
  • endometrial glandular cells: 92 nCPM
  • cytotrophoblasts: 42 nCPM
  • pancreatic acinar cells: 38 nCPM

Immune cell

  • basophil: 0.9 nTPM
  • neutrophil: 0.5 nTPM
  • NK-cell: 0.3 nTPM
  • naive B-cell: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • cerebellum: 8.9 nTPM
  • cerebral cortex: 6.9 nTPM
  • hippocampal formation: 6.1 nTPM
  • basal ganglia: 6 nTPM
  • choroid plexus: 5.9 nTPM
  • hypothalamus: 5.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC30A2.

Disease | AllUniProt

Conditions SLC30A2 is implicated in, by any mechanism.

  • Zinc deficiency, transient neonatal (TNZD) MIM:608118

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 58 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Zinc deficiency, transient neonatal

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.08
gnomAD missense Z
0.93
DepMap mean gene effect
0.16
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A2 as an antibody target. Whether an autoantibody or antibody against SLC30A2 could matter depends on whether native SLC30A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A2 is annotated at the cell surface, where native SLC30A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC30A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC30A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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