Seroatlas · Human Serome Atlas

SLC30A8

Proton-coupled zinc antiporter SLC30A8

Also known as: ZnT-8, ZNT8, ZNT8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IWU4
Gene
SLC30A8
Ensembl
ENSG00000164756
Chromosome
8
Canonical length
369 aa
Protein class
Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q8IWU4|SLC30A8
     1  MEFLERTYLV NDKAAKMYAF TLESVELQQK PVNKDQCPRE RPEELESGGM YHCHSGSKPT
    61  EKGANEYAYA KWKLCSASAI CFIFMIAEVV GGHIAGSLAV VTDAAHLLID LTSFLLSLFS
   121  LWLSSKPPSK RLTFGWHRAE ILGALLSILC IWVVTGVLVY LACERLLYPD YQIQATVMII
   181  VSSCAVAANI VLTVVLHQRC LGHNHKEVQA NASVRAAFVH ALGDLFQSIS VLISALIIYF
   241  KPEYKIADPI CTFIFSILVL ASTITILKDF SILLMEGVPK SLNYSGVKEL ILAVDGVLSV
   301  HSLHIWSLTM NQVILSAHVA TAASRDSQVV RREIAKALSK SFTMHSLTIQ MESPVDQDPD
   361  CLFCEDPCD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 49 nTPM
  • salivary gland: 12 nTPM
  • kidney: 3.8 nTPM
  • testis: 1.6 nTPM
  • stomach: 1 nTPM
  • small intestine: 0.8 nTPM

Single-cell type

  • pancreatic islet cells: 665 nCPM
  • proximal tubule cells: 133 nCPM
  • undifferentiated spermatogonia: 91 nCPM
  • differentiating spermatogonia: 55 nCPM
  • early primary spermatocytes: 47 nCPM
  • late primary spermatocytes: 21 nCPM

Immune cell

  • gdT-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • basal ganglia: 2.2 nTPM
  • pons: 2.1 nTPM
  • cerebral cortex: 1.9 nTPM
  • hippocampal formation: 1.9 nTPM
  • cerebellum: 1.8 nTPM
  • white matter: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC30A8.

Disease | ImmuneIEDB

Conditions an epitope on SLC30A8 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against SLC30A8 are reported. Each links to that disease's full target list.

Showing 2 of 3 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for SLC30A8 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

86 publications

Show 20 more of 86 total

Reference: B cellIEDB

6 publications

Show 1 more

Reference: T cellIEDB

6 publications

Show 1 more

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.52
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A8 as an antibody target. Whether an autoantibody or antibody against SLC30A8 could matter depends on whether native SLC30A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A8 is annotated at the cell surface, where native SLC30A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC30A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC30A8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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