Seroatlas · Human Serome Atlas

SLC30A7

Zinc transporter 7

Also known as: ZNT7, ZNT7_HUMAN, ZnTL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEW0
Gene: SLC30A7
Ensembl: ENSG00000162695
Chromosome: 1
Canonical length: 376 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus
Quaternary structure: Homooligomer

OverviewNCBI Gene

Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q8NEW0|SLC30A7
     1  MLPLSIKDDE YKPPKFNLFG KISGWFRSIL SDKTSRNLFF FLCLNLSFAF VELLYGIWSN
    61  CLGLISDSFH MFFDSTAILA GLAASVISKW RDNDAFSYGY VRAEVLAGFV NGLFLIFTAF
   121  FIFSEGVERA LAPPDVHHER LLLVSILGFV VNLIGIFVFK HGGHGHSHGS GHGHSHSLFN
   181  GALDQAHGHV DHCHSHEVKH GAAHSHDHAH GHGHFHSHDG PSLKETTGPS RQILQGVFLH
   241  ILADTLGSIG VIASAIMMQN FGLMIADPIC SILIAILIVV SVIPLLRESV GILMQRTPPL
   301  LENSLPQCYQ RVQQLQGVYS LQEQHFWTLC SDVYVGTLKL IVAPDADARW ILSQTHNIFT
   361  QAGVRQLYVQ IDFAAM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

liver: 9.5 nTPM
lung: 8.2 nTPM
placenta: 8.2 nTPM
salivary gland: 7.4 nTPM
epididymis: 7.3 nTPM
urinary bladder: 7.3 nTPM

Single-cell type

corticotrophs: 127 nCPM
plasma cells: 109 nCPM
prostatic glandular cells: 107 nCPM
gonadotrophs: 107 nCPM
vascular endothelial cells: 106 nCPM
pituicytes/fscs: 104 nCPM

Immune cell

non-classical monocyte: 8.7 nTPM
basophil: 8.3 nTPM
intermediate monocyte: 6.5 nTPM
classical monocyte: 5.8 nTPM
naive CD8 T-cell: 5.7 nTPM
naive CD4 T-cell: 5.5 nTPM

Brain region

choroid plexus: 17 nTPM
white matter: 11 nTPM
cerebellum: 11 nTPM
thalamus: 10 nTPM
midbrain: 10 nTPM
cerebral cortex: 9.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC30A7.

Disease | AllUniProt

Conditions SLC30A7 is implicated in, by any mechanism.

Ziegler-Huang syndrome (ZHS) MIM:620501

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 91 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Ziegler-Huang syndrome
Joubert syndrome 1
Decreased testicular size
Testicular atrophy
Severe early-onset pulmonary alveolar proteinosis due to MARS deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A7 as an antibody target. Whether an autoantibody or antibody against SLC30A7 could matter depends on whether native SLC30A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC30A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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