Seroatlas · Human Serome Atlas

SLC30A1

Proton-coupled zinc antiporter SLC30A1

Also known as: ZNT1, ZNT1_HUMAN, ZRC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y6M5
Gene
SLC30A1
Ensembl
ENSG00000170385
Chromosome
1
Canonical length
507 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable calcium channel inhibitor activity and zinc:proton antiporter activity. Involved in defense response to bacterium; intracellular zinc ion homeostasis; and zinc ion import into organelle. Located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q9Y6M5|SLC30A1
     1  MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF
    61  ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFIEPHEM QQPLVVLGVG
   121  VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH GGHGHGHGLP KGPRVKSTRP GSSDINVAPG
   181  EQGPDQEETN TLVANTSNSN GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA
   241  GQLNMRGVFL HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS
   301  THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ IDIRNLIKEL
   361  RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA KTIKDVFHNH GIHATTIQPE
   421  FASVGSKSSV VPCELACRTQ CALKQCCGTL PQAPSGKDAE KTPAVSISCL ELSNNLEKKP
   481  RRTKAENIPA VVIEIKNMPN KQPESSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
81 nTPM

Expression across tissuesHPA

Tissue

  • liver: 81 nTPM
  • bone marrow: 28 nTPM
  • duodenum: 27 nTPM
  • kidney: 19 nTPM
  • small intestine: 19 nTPM
  • cervix: 18 nTPM

Single-cell type

  • hepatocytes: 106 nCPM
  • epididymal efferent duct ciliated cells: 98 nCPM
  • endometrial luminal cells: 77 nCPM
  • epididymal efferent duct absorptive cells: 77 nCPM
  • endometrial glandular cells: 72 nCPM
  • late primary spermatocytes: 70 nCPM

Immune cell

  • intermediate monocyte: 1.5 nTPM
  • basophil: 1.4 nTPM
  • classical monocyte: 1.3 nTPM
  • non-classical monocyte: 1.2 nTPM
  • myeloid DC: 0.9 nTPM
  • eosinophil: 0.5 nTPM

Brain region

  • choroid plexus: 50 nTPM
  • thalamus: 32 nTPM
  • medulla oblongata: 29 nTPM
  • midbrain: 28 nTPM
  • pons: 27 nTPM
  • basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.23
gnomAD pLI
0.99
gnomAD missense Z
2.2
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A1 as an antibody target. Whether an autoantibody or antibody against SLC30A1 could matter depends on whether native SLC30A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A1 is annotated at the cell surface, where native SLC30A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC30A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC30A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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