Seroatlas · Human Serome Atlas

SLC30A3

Probable proton-coupled zinc antiporter SLC30A3

Also known as: ZNT3, ZNT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99726
Gene: SLC30A3
Ensembl: ENSG00000115194
Chromosome: 2
Canonical length: 388 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Nucleoli,Vesicles,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables zinc ion transmembrane transporter activity. Involved in zinc ion import into lysosome. Located in late endosome and synaptic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q99726|SLC30A3
     1  MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM PFHHCHRDPL
    61  PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL AIMTDAAHLL ADVGSMMGSL
   121  FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM
   181  LLTASIAVCA NLLMAFVLHQ AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL
   241  GDLLQSFGVL AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV
   301  GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF
   361  GFSSCTLQVE QYQPEMAQCL RCQEPPQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC30A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

epididymis: 65 nTPM
testis: 32 nTPM
cerebral cortex: 30 nTPM
amygdala: 19 nTPM
hippocampal formation: 15 nTPM
heart muscle: 7.1 nTPM

Single-cell type

epididymal principal cells: 334 nCPM
cardiomyocytes: 134 nCPM
late spermatids: 75 nCPM
sertoli cells: 63 nCPM
late primary spermatocytes: 27 nCPM
brain excitatory neurons: 26 nCPM

Immune cell

basophil: 0.4 nTPM
neutrophil: 0.3 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

hippocampal formation: 70 nTPM
cerebral cortex: 62 nTPM
amygdala: 54 nTPM
basal ganglia: 41 nTPM
white matter: 27 nTPM
medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.54
gnomAD missense Z: 1.73
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC30A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC30A3 as an antibody target. Whether an autoantibody or antibody against SLC30A3 could matter depends on whether native SLC30A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC30A3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC30A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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