Seroatlas · Human Serome Atlas

NXT2

NTF2-related export protein 2

Also known as: NXT2_HUMAN, P15-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPJ8
Gene: NXT2
Ensembl: ENSG00000101888
Chromosome: X
Canonical length: 142 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q9NPJ8|NXT2
     1  MATSLDFKTY VDQACRAAEE FVNIYYETMD KRRRALTRLY LDKATLIWNG NAVSGLDALN
    61  NFFDTLPSSE FQVNMLDCQP VHEQATQSQT TVLVVTSGTV KFDGNKQHFF NQNFLLTAQS
   121  TPNNTVWKIA SDCFRFQDWS SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NXT2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

testis: 26 nTPM
bone marrow: 17 nTPM
breast: 14 nTPM
thymus: 14 nTPM
tonsil: 13 nTPM
lymph node: 12 nTPM

Single-cell type

late primary spermatocytes: 35 nCPM
parietal cells: 34 nCPM
syncytiotrophoblasts: 33 nCPM
early primary spermatocytes: 33 nCPM
extravillous trophoblasts: 33 nCPM
differentiating spermatogonia: 29 nCPM

Immune cell

NK-cell: 11 nTPM
intermediate monocyte: 9.8 nTPM
myeloid DC: 9.7 nTPM
gdT-cell: 9.2 nTPM
T-reg: 8.4 nTPM
non-classical monocyte: 8.1 nTPM

Brain region

spinal cord: 10 nTPM
white matter: 9.6 nTPM
medulla oblongata: 9.1 nTPM
cerebellum: 8.2 nTPM
midbrain: 8 nTPM
hypothalamus: 7.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NXT2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 48 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.83
gnomAD missense Z: 1.12
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NXT2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NXT2 as an antibody target. Whether an autoantibody or antibody against NXT2 could matter depends on whether native NXT2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NXT2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NXT2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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