Seroatlas · Human Serome Atlas

ZC3H12D

Probable ribonuclease ZC3H12D

Also known as: C6orf95, dJ281H8.1, MCPIP4, ZC12D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A2A288
Gene: ZC3H12D
Ensembl: ENSG00000178199
Chromosome: 6
Canonical length: 527 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytoplasmic bodies

OverviewNCBI Gene

Predicted to enable RNA endonuclease activity and mRNA binding activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of cell growth. Located in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>A2A288|ZC3H12D
     1  MEHPSKMEFF QKLGYDREDV LRVLGKLGEG ALVNDVLQEL IRTGSRPGAL EHPAAPRLVP
    61  RGSCGVPDSA QRGPGTALEE DFRTLASSLR PIVIDGSNVA MSHGNKETFS CRGIKLAVDW
   121  FRDRGHTYIK VFVPSWRKDP PRADTPIREQ HVLAELERQA VLVYTPSRKV HGKRLVCYDD
   181  RYIVKVAYEQ DGVIVSNDNY RDLQSENPEW KWFIEQRLLM FSFVNDRFMP PDDPLGRHGP
   241  SLSNFLSRKP KPPEPSWQHC PYGKKCTYGI KCKFYHPERP HHAQLAVADE LRAKTGARPG
   301  AGAEEQRPPR APGGSAGARA APREPFAHSL PPARGSPDLA ALRGSFSRLA FSDDLGPLGP
   361  PLPVPACSLT PRLGGPDWVS AGGRVPGPLS LPSPESQFSP GDLPPPPGLQ LQPRGEHRPR
   421  DLHGDLLSPR RPPDDPWARP PRSDRFPGRS VWAEPAWGDG ATGGLSVYAT EDDEGDARAR
   481  ARIALYSVFP RDQVDRVMAA FPELSDLARL ILLVQRCQSA GAPLGKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZC3H12D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

tonsil: 12 nTPM
lymph node: 9.2 nTPM
appendix: 6.7 nTPM
spleen: 5.5 nTPM
small intestine: 4.4 nTPM
bone marrow: 3.4 nTPM

Single-cell type

t-cells: 53 nCPM
b-cells: 40 nCPM
kupffer cells: 29 nCPM
macrophages: 22 nCPM
cdc: 16 nCPM
microglia: 15 nCPM

Immune cell

T-reg: 3.5 nTPM
memory CD4 T-cell: 1.5 nTPM
memory B-cell: 1.4 nTPM
non-classical monocyte: 1.4 nTPM
naive B-cell: 1.3 nTPM
naive CD4 T-cell: 0.9 nTPM

Brain region

medulla oblongata: 4.9 nTPM
cerebral cortex: 4.8 nTPM
amygdala: 4.6 nTPM
hypothalamus: 4.6 nTPM
pons: 4.6 nTPM
white matter: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.16
gnomAD missense Z: 1.4

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZC3H12D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZC3H12A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZC3H12D as an antibody target. Whether an autoantibody or antibody against ZC3H12D could matter depends on whether native ZC3H12D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZC3H12D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZC3H12D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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