Seroatlas · Human Serome Atlas

AHSP

Alpha-hemoglobin-stabilizing protein

Also known as: AHSP_HUMAN, EDRF, ERAF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZD4
Gene: AHSP
Ensembl: ENSG00000169877
Chromosome: 16
Canonical length: 102 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a molecular chaperone which binds specifically to free alpha-globin and is involved in hemoglobin assembly. The encoded protein binds to monomeric alpha-globin until it has been transferred to beta-globin to form a heterodimer, which in turn binds to another heterodimer to form the stable tetrameric hemoglobin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

102 residues, UniProt reviewed canonical sequence.

>Q9NZD4|AHSP
     1  MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP
    61  QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AHSP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 1,571 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 1,571 nTPM
placenta: 25 nTPM
spleen: 25 nTPM
tongue: 8.3 nTPM
liver: 5 nTPM
lung: 5 nTPM

Single-cell type

erythrocyte progenitors: 2,431 nCPM
erythrocytes: 2,027 nCPM
megakaryocyte-erythroid progenitors: 44 nCPM
late spermatids: 38 nCPM
early spermatids: 38 nCPM
late primary spermatocytes: 13 nCPM

Immune cell

total PBMC: 4.7 nTPM
neutrophil: 0.5 nTPM
memory B-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

medulla oblongata: 0.5 nTPM
white matter: 0.5 nTPM
cerebral cortex: 0.4 nTPM
midbrain: 0.4 nTPM
pons: 0.4 nTPM
spinal cord: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -0.25
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Alpha-haemoglobin stabilising protein
AHSP superfamily
Alpha-haemoglobin stabilising protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AHSP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ZC3H12A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AHSP as an antibody target. Whether an autoantibody or antibody against AHSP could matter depends on whether native AHSP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AHSP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AHSP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...