Ribonuclease Zc3h12a-like, NYN domain

Definition

This domain is found in the Zc3h12a protein and NEDD4-binding protein 1 (N4BP1). Zc3h12a has been shown to be a ribonuclease that controls the stability of a set of inflammatory genes PMID:19322177. This domain belongs to the PIN domain superfamily PMID:19322177 and it has also been identified as part of the NYN domain family PMID:17114934. N4BP1 is a potent suppressor of cytokine production that acts as a regulator of innate immune signalling and inflammation PMID:32971525. It acts as a restriction factor against some viruses, such as HIV-1. N4BP1 restricts HIV-1 replication by binding to HIV-1 mRNAs and mediating their degradation via its ribonuclease activity PMID:31133753.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• KHNYN
• N4BP1
• NYNRIN
• ZC3H12A
• ZC3H12B
• ZC3H12C
• ZC3H12D