ZC3H12/N4BP1 Ribonuclease and Regulator
IPR051101
Definition
The ZC3H12/N4BP1 protein family includes endoribonucleases and regulatory proteins involved in various biological processes such as immune homeostasis, inflammation, glial differentiation, apoptosis, adipogenesis, and angiogenesis. Members of the family function as RNases, regulating mRNA and pre-miRNA levels, thereby influencing cytokine production, T-cell activation, and stress response. They also modulate ubiquitination processes, affecting signaling pathways like NF-kappa-B and JNK. Some members serve as tumor suppressors or restrict viral replication. The family is characterized by a C3H1-type zinc finger domain essential for RNA binding and a proline-rich domain necessary for oligomerization.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...