Seroatlas · Human Serome Atlas

WWTR1

WW domain-containing transcription regulator protein 1

Also known as: DKFZp586I1419, TAZ, WWTR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9GZV5
Gene
WWTR1
Ensembl
ENSG00000018408
Chromosome
3
Canonical length
400 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in several processes, including intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; and positive regulation of cell differentiation. Located in cytosol and nuclear body. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

400 residues, UniProt reviewed canonical sequence.

>Q9GZV5|WWTR1
     1  MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS
    61  HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV
   121  TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR
   181  SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ QQQKLRLQRI
   241  QMERERIRMR QEELMRQEAA LCRQLPMEAE TLAPVQAAVN PPTMTPDMRS ITNNSSDPFL
   301  NGGPYHSREQ STDSGLGLGC YSVPTTPEDF LSNVDEMDTG ENAGQTPMNI NPQQTRFPDF
   361  LDCLPGTNVD LGTLESEDLI PLFNDVESAL NKSEPFLTWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WWTR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • colon: 63 nTPM
  • blood vessel: 59 nTPM
  • ovary: 44 nTPM
  • kidney: 43 nTPM
  • urinary bladder: 42 nTPM
  • placenta: 41 nTPM

Single-cell type

  • vascular endothelial cells: 781 nCPM
  • lymphatic endothelial cells: 577 nCPM
  • endometrial ciliated cells: 565 nCPM
  • transitional alveolar cells: 546 nCPM
  • epididymal basal cells: 538 nCPM
  • endometrial luminal cells: 532 nCPM

Immune cell

  • memory CD8 T-cell: 0.8 nTPM
  • gdT-cell: 0.7 nTPM
  • T-reg: 0.5 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • basophil: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • hypothalamus: 121 nTPM
  • medulla oblongata: 116 nTPM
  • midbrain: 89 nTPM
  • white matter: 88 nTPM
  • spinal cord: 84 nTPM
  • choroid plexus: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.94
gnomAD missense Z
1.12
DepMap mean gene effect
-0.35
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WWTR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WWTR1 as an antibody target. Whether an autoantibody or antibody against WWTR1 could matter depends on whether native WWTR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WWTR1 is annotated at the cell surface, where native WWTR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label WWTR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WWTR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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