TEAD1

Protein identityUniProt · HPA

UniProt accession

P28347

Gene

TEAD1

Ensembl

ENSG00000187079

Chromosome

11

Canonical length

426 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>P28347|TEAD1
     1  MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL
    61  SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSRDFHSKLK DQTAKDKALQ
   121  HMAAMSSAQI VSATAIHNKL GLPGIPRPTF PGAPGFWPGM IQTGQPGSSQ DVKPFVQQAY
   181  PIQPAVTAPI PGFEPASAPA PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV
   241  HIGHANHSYS DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD
   301  DAGAFYGVTS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV YRINRSPMCE
   361  YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL LCMACVFEVS NSEHGAQHHI
   421  YRLVKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

68 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TEAD1.

Disease | AllUniProt

Conditions TEAD1 is implicated in, by any mechanism.

• Sveinsson chorioretinal atrophy (SCRA) MIM:108985

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 289 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Helicoid peripapillary chorioretinal degeneration

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.12

gnomAD pLI

1

gnomAD missense Z

1.66

DepMap mean gene effect

-0.24

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• embryonic organ development
• hippo signaling
• positive regulation of cell growth
• positive regulation of DNA-templated transcription
• positive regulation of miRNA transcription
• positive regulation of transcription by RNA polymerase II
• protein-containing complex assembly
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA binding
• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• sequence-specific double-stranded DNA binding

Cellular components

• chromatin
• nucleoplasm
• nucleus
• TEAD-YAP complex
• transcription regulator complex

Protein domainsUniProt · Pfam · InterPro

• TEA/ATTS domain
• Transcriptional enhancer factor, metazoa
• TEA/ATTS domain superfamily
• YAP binding domain
• TEA/ATTS domain
• YAP binding domain

KeywordsUniProt

• Acetylation
• Activator
• DNA-binding
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TEAD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• YAP1
• WWTR1