Seroatlas · Human Serome Atlas

SH3YL1

SH3 domain-containing YSC84-like protein 1

Also known as: DKFZP586F1318, Ray, SH3Y1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HL8
Gene: SH3YL1
Ensembl: ENSG00000035115
Chromosome: 2
Canonical length: 342 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables phosphatase binding activity and phosphatidylinositol binding activity. Predicted to be involved in regulation of ruffle assembly. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Located in ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q96HL8|SH3YL1
     1  MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAIL SVIKAGFLVT
    61  ARGGSGIVVA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL
   121  TLGGNLTVAV GPLGRNLEGN VALRSSAAVF TYCKSRGLFA GVSLEGSCLI ERKETNRKFY
   181  CQDIRAYDIL FGDTPRPAQA EDLYEILDSF TEKYENEGQR INARKAAREQ RKSSAKELPP
   241  KPLSRPQQSS APVQLNSGSQ SNRNEYKLYP GLSSYHERVG NLNQPIEVTA LYSFEGQQPG
   301  DLNFQAGDRI TVISKTDSHF DWWEGKLRGQ TGIFPANYVT MN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3YL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 153 nTPM

Expression across tissuesHPA

Tissue

pancreas: 153 nTPM
kidney: 136 nTPM
salivary gland: 107 nTPM
skin: 71 nTPM
stomach: 68 nTPM
thyroid gland: 55 nTPM

Single-cell type

esophageal apical cells: 542 nCPM
parietal cells: 513 nCPM
cholangiocytes: 438 nCPM
syncytiotrophoblasts: 357 nCPM
pancreatic duct cells: 344 nCPM
urothelial cells: 324 nCPM

Immune cell

basophil: 39 nTPM
naive CD4 T-cell: 34 nTPM
T-reg: 31 nTPM
NK-cell: 23 nTPM
memory CD4 T-cell: 22 nTPM
naive CD8 T-cell: 21 nTPM

Brain region

white matter: 38 nTPM
choroid plexus: 30 nTPM
medulla oblongata: 29 nTPM
pons: 29 nTPM
thalamus: 29 nTPM
basal ganglia: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

ruffle membrane

Protein domainsUniProt · Pfam · InterPro

SH3 domain
SH3-like domain superfamily
Variant SH3 domain
Ysc84 actin-binding domain
SH3YL1-like, SYLF domain
SH3YL1, SH3 domain
SH3 domain-containing protein YSC84-like
Las17-binding protein actin regulator

KeywordsUniProt

SH3 domain

InteractionsUniProt · HPA

Protein binding partners of SH3YL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3YL1 as an antibody target. Whether an autoantibody or antibody against SH3YL1 could matter depends on whether native SH3YL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3YL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3YL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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