Helix hairpin bin domain superfamily

Definition

This domain superfamily is found in uncharacterised protein whose genomic location within nitrogen fixation clusters suggests that they may play a role in this process. They consist of two α-helices. A four-residue linker between the helices allows them to form an anti-parallel bundle and cross over each other towards their termini PMID:19336042. A similar domain is found in Sulfolobus spindle-shaped virus 1 (SSV1) protein D-63 PMID:15220417. This domain is also present in eukaryotic proteins such as Golgi to ER traffic protein 1 (GET1), also known as tail-anchored protein insertion receptor WRB, Pre-mRNA-splicing factor ISY1 and Vacuolar protein sorting-associated protein 37.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• GET1
• ISY1
• VPS37A
• VPS37B
• VPS37C