Seroatlas · Human Serome Atlas

MON1B

Vacuolar fusion protein MON1 homolog B

Also known as: HSRG1, KIAA0872, MON1B_HUMAN, SAND2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7L1V2
Gene
MON1B
Ensembl
ENSG00000103111
Chromosome
16
Canonical length
547 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Involved in early viral transcription and late viral transcription. Located in cytoplasm. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

547 residues, UniProt reviewed canonical sequence.

>Q7L1V2|MON1B
     1  MEVGGDTAAP APGGAEDLED TQFPSEEARE GGGVHAVPPD PEDEGLEETG SKDKDQPPSP
    61  SPPPQSEALS STSRLWSPAA PENSPTCSPE SSSGGQGGDP SDEEWRSQRK HVFVLSEAGK
   121  PIYSRYGSVE ALSATMGVMT ALVSFVQSAG DAIRAIYAED HKLVFLQQGP LLLVAMSRTS
   181  QSAAQLRGEL LAVHAQIVST LTRASVARIF AHKQNYDLRR LLAGSERTLD RLLDSMEQDP
   241  GALLLGAVRC VPLARPLRDA LGALLRRCTA PGLALSVLAV GGRLITAAQE RNVLAECRLD
   301  PADLQLLLDW VGAPAFAAGE AWAPVCLPRF NPDGFFYAYV ARLDAMPVCL LLLGTQREAF
   361  HAMAACRRLV EDGMHALGAM RALGEAASFS NASSASAPAY SVQAVGAPGL RHFLYKPLDI
   421  PDHHRQLPQF TSPELEAPYS REEERQRLSD LYHRLHARLH STSRPLRLIY HVAEKETLLA
   481  WVTSKFELYT CLSPLVTKAG AILVVTKLLR WVKKEEDRLF IRYPPKYSTP PATSTDQAAH
   541  NGLFTGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MON1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • retina: 19 nTPM
  • spinal cord: 19 nTPM
  • prostate: 19 nTPM
  • thyroid gland: 18 nTPM
  • lymph node: 17 nTPM
  • midbrain: 17 nTPM

Single-cell type

  • neutrophils: 29 nCPM
  • early spermatids: 22 nCPM
  • prostatic glandular cells: 20 nCPM
  • cone photoreceptor cells: 19 nCPM
  • late spermatids: 18 nCPM
  • breast lactating cells: 16 nCPM

Immune cell

  • neutrophil: 22 nTPM
  • basophil: 18 nTPM
  • eosinophil: 17 nTPM
  • intermediate monocyte: 16 nTPM
  • non-classical monocyte: 11 nTPM
  • NK-cell: 10 nTPM

Brain region

  • basal ganglia: 54 nTPM
  • medulla oblongata: 53 nTPM
  • midbrain: 51 nTPM
  • thalamus: 49 nTPM
  • white matter: 47 nTPM
  • pons: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.6
gnomAD pLI
0.02
gnomAD missense Z
0.85
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MON1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MON1B as an antibody target. Whether an autoantibody or antibody against MON1B could matter depends on whether native MON1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MON1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MON1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MON1B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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