ATP2A3

Protein identityUniProt · HPA

UniProt accession

Q93084

Gene

ATP2A3

Ensembl

ENSG00000074370

Chromosome

17

Canonical length

999 aa

Protein class

Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

999 residues, UniProt reviewed canonical sequence.

>Q93084|ATP2A3
     1  MEAAHLLPAA DVLRHFSVTA EGGLSPAQVT GARERYGPNE LPSEEGKSLW ELVLEQFEDL
    61  LVRILLLAAL VSFVLAWFEE GEETTTAFVE PLVIMLILVA NAIVGVWQER NAESAIEALK
   121  EYEPEMGKVI RSDRKGVQRI RARDIVPGDI VEVAVGDKVP ADLRLIEIKS TTLRVDQSIL
   181  TGESVSVTKH TEAIPDPRAV NQDKKNMLFS GTNITSGKAV GVAVATGLHT ELGKIRSQMA
   241  AVEPERTPLQ RKLDEFGRQL SHAISVICVA VWVINIGHFA DPAHGGSWLR GAVYYFKIAV
   301  ALAVAAIPEG LPAVITTCLA LGTRRMARKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ
   361  MSVCRMFVVA EADAGSCLLH EFTISGTTYT PEGEVRQGDQ PVRCGQFDGL VELATICALC
   421  NDSALDYNEA KGVYEKVGEA TETALTCLVE KMNVFDTDLQ ALSRVERAGA CNTVIKQLMR
   481  KEFTLEFSRD RKSMSVYCTP TRPHPTGQGS KMFVKGAPES VIERCSSVRV GSRTAPLTPT
   541  SREQILAKIR DWGSGSDTLR CLALATRDAP PRKEDMELDD CSKFVQYETD LTFVGCVGML
   601  DPPRPEVAAC ITRCYQAGIR VVMITGDNKG TAVAICRRLG IFGDTEDVAG KAYTGREFDD
   661  LSPEQQRQAC RTARCFARVE PAHKSRIVEN LQSFNEITAM TGDGVNDAPA LKKAEIGIAM
   721  GSGTAVAKSA AEMVLSDDNF ASIVAAVEEG RAIYSNMKQF IRYLISSNVG EVVCIFLTAI
   781  LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMEKL PRSPREALIS GWLFFRYLAI
   841  GVYVGLATVA AATWWFVYDA EGPHINFYQL RNFLKCSEDN PLFAGIDCEV FESRFPTTMA
   901  LSVLVTIEMC NALNSVSENQ SLLRMPPWMN PWLLVAVAMS MALHFLILLV PPLPLIFQVT
   961  PLSGRQWVVV LQISLPVILL DEALKYLSRN HMHEEMSQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP2A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

10

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

175 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.66

gnomAD pLI

0

gnomAD missense Z

1.83

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium ion transmembrane transport
• calcium ion transport
• calcium ion transport from cytosol to endoplasmic reticulum
• intracellular calcium ion homeostasis
• intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
• monoatomic ion transmembrane transport
• regulation of cardiac conduction
• transport across blood-brain barrier

Molecular functions

• ATP binding
• ATP hydrolysis activity
• calcium channel regulator activity
• calcium ion transmembrane transporter activity
• calcium-dependent ATPase activity
• cysteine-type endopeptidase activator activity involved in apoptotic process
• metal ion binding
• P-type calcium transporter activity
• transmembrane transporter binding

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• membrane
• nuclear membrane
• organelle membrane
• platelet dense tubular network membrane
• sarcoplasmic reticulum
• sarcoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

• P-type ATPase
• Cation-transporting P-type ATPase, N-terminal
• P-type ATPase, subfamily IIA, SERCA-type
• Cation-transporting P-type ATPase, C-terminal
• P-type ATPase, A domain superfamily
• P-type ATPase, phosphorylation site
• HAD superfamily
• P-type ATPase, transmembrane domain superfamily
• P-type ATPase, cytoplasmic domain N
• HAD-like superfamily
• P-type ATPase, haloacid dehalogenase domain
• P-type ATPase, A domain
• P-type ATPase actuator domain
• Cation transporting ATPase, C-terminus
• Cation transporter/ATPase, N-terminus
• haloacid dehalogenase-like hydrolase
• P-type ATPase, cytoplasmic domain N

KeywordsUniProt

• Acetylation
• ATP-binding
• Calcium
• Calcium transport
• Endoplasmic reticulum
• Ion transport
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Sarcoplasmic reticulum
• Translocase
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP2A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DWORF
• TUNAR
• VMP1