Seroatlas · Human Serome Atlas

PLN

Phospholamban

Also known as: CMD1P, PLB, PPLA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P26678
Gene
PLN
Ensembl
ENSG00000198523
Chromosome
6
Canonical length
52 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Quaternary structure
Homopentamer

OverviewNCBI Gene

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

52 residues, UniProt reviewed canonical sequence.

>P26678|PLN
     1  MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM LL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
1,463 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 1,463 nTPM
  • skeletal muscle: 475 nTPM
  • blood vessel: 341 nTPM
  • tongue: 215 nTPM
  • smooth muscle: 120 nTPM
  • colon: 106 nTPM

Single-cell type

  • vascular smooth muscle cells: 699 nCPM
  • smooth muscle cells: 561 nCPM
  • myonuclei: 207 nCPM
  • cardiomyocytes: 167 nCPM
  • late primary spermatocytes: 119 nCPM
  • early spermatids: 103 nCPM

Immune cell

  • eosinophil: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • basal ganglia: 7 nTPM
  • cerebellum: 6.3 nTPM
  • cerebral cortex: 5.2 nTPM
  • thalamus: 4.9 nTPM
  • midbrain: 4.6 nTPM
  • pons: 4.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PLN.

Disease | AllUniProt

Conditions PLN is implicated in, by any mechanism.

  • Cardiomyopathy, dilated, 1P (CMD1P) MIM:609909
  • Cardiomyopathy, familial hypertrophic, 18 (CMH18) MIM:613874

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 156 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0.45
gnomAD missense Z
0.62
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Phospholamban
  • Phospholamban

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLN as an antibody target. Whether an autoantibody or antibody against PLN could matter depends on whether native PLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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