SLN

Protein identityUniProt · HPA

UniProt accession

O00631

Gene

SLN

Ensembl

ENSG00000170290

Chromosome

11

Canonical length

31 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Microtubules

Quaternary structure

Homooligomer

OverviewNCBI Gene

Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

31 residues, UniProt reviewed canonical sequence.

>O00631|SLN
     1  MGINTRELFL NFTIVLITVI LMWLLVRSYQ Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

7,680 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.89

gnomAD pLI

0.29

gnomAD missense Z

0.19

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• calcium ion transport
• negative regulation of ATPase-coupled calcium transmembrane transporter activity
• negative regulation of calcium ion import
• negative regulation of calcium ion import into sarcoplasmic reticulum
• negative regulation of protein-containing complex disassembly
• positive regulation of cold-induced thermogenesis
• regulation of ATPase-coupled calcium transmembrane transporter activity
• regulation of calcium ion transport
• regulation of relaxation of muscle
• sarcoplasmic reticulum calcium ion transport
• positive regulation of protein depolymerization

Molecular functions

• ATPase binding
• enzyme inhibitor activity

Cellular components

• membrane
• sarcoplasmic reticulum
• sarcoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

• Sarcolipin
• Sarcolipin

KeywordsUniProt

• Endoplasmic reticulum
• Membrane
• Sarcoplasmic reticulum
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of SLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• VMP1