Seroatlas · Human Serome Atlas

ATG2A

Autophagy-related protein 2 homolog A

Also known as: ATG2A_HUMAN, BLTP4A, KIAA0404

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2TAZ0
Gene: ATG2A
Ensembl: ENSG00000110046
Chromosome: 11
Canonical length: 1938 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables lipid transfer activity. Involved in autophagosome assembly and positive regulation of autophagosome assembly. Is active in organelle membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1938 residues, UniProt reviewed canonical sequence.

>Q2TAZ0|ATG2A
     1  MSRWLWPWSN CVKERVCRYL LHHYLGHFFQ EHLSLDQLSL DLYKGSVALR DIHLEIWSVN
    61  EVLESMESPL ELVEGFVGSI EVAVPWAALL TDHCTVRVSG LQLTLQPRRG PAPGAADSQS
   121  WASCMTTSLQ LAQECLRDGL PEPSEPPQPL EGLEMFAQTI ETVLRRIKVT FLDTVVRVEH
   181  SPGDGERGVA VEVRVQRLEY CDEAVRDPSQ APPVDVHQPP AFLHKLLQLA GVRLHYEELP
   241  AQEEPPEPPL QIGSCSGYME LMVKLKQNEA FPGPKLEVAG QLGSLHLLLT PRQLQQLQEL
   301  LSAVSLTDHE GLADKLNKSR PLGAEDLWLI EQDLNQQLQA GAVAEPLSPD PLTNPLLNLD
   361  NTDLFFSMAG LTSSVASALS ELSLSDVDLA SSVRSDMASR RLSAQAHPAG KMAPNPLLDT
   421  MRPDSLLKMT LGGVTLTLLQ TSAPSSGPPD LATHFFTEFD ATKDGPFGSR DFHHLRPRFQ
   481  RACPCSHVRL TGTAVQLSWE LRTGSRGRRT TSMEVHFGQL EVLECLWPRG TSEPEYTEIL
   541  TFPGTLGSQA SARPCAHLRH TQILRRVPKS RPRRSVACHC HSELALDLAN FQADVELGAL
   601  DRLAALLRLA TVPAEPPAGL LTEPLPAMEQ QTVFRLSAPR ATLRLRFPIA DLRPEPDPWA
   661  GQAVRAEQLR LELSEPQFRS ELSSGPGPPV PTHLELTCSD LHGIYEDGGK PPVPCLRVSK
   721  ALDPKSTGRK YFLPQVVVTV NPQSSSTQWE VAPEKGEELE LSVESPCELR EPEPSPFSSK
   781  RTMYETEEMV IPGDPEEMRT FQSRTLALSR CSLEVILPSV HIFLPSKEVY ESIYNRINND
   841  LLMWEPADLL PTPDPAAQPS GFPGPSGFWH DSFKMCKSAF KLANCFDLTP DSDSDDEDAH
   901  FFSVGASGGP QAAAPEAPSL HLQSTFSTLV TVLKGRITAL CETKDEGGKR LEAVHGELVL
   961  DMEHGTLFSV SQYCGQPGLG YFCLEAEKAT LYHRAAVDDY PLPSHLDLPS FAPPAQLAPT
  1021  IYPSEEGVTE RGASGRKGQG RGPHMLSTAV RIHLDPHKNV KEFLVTLRLH KATLRHYMAL
  1081  PEQSWHSQLL EFLDVLDDPV LGYLPPTVIT ILHTHLFSCS VDYRPLYLPV RVLITAETFT
  1141  LSSNIIMDTS TFLLRFILDD SALYLSDKCE VETLDLRRDY VCVLDVDLLE LVIKTWKGST
  1201  EGKLSQPLFE LRCSNNVVHV HSCADSCALL VNLLQYVMST GDLHPPPRPP SPTEIAGQKL
  1261  SESPASLPSC PPVETALINQ RDLADALLDT ERSLRELAQP SGGHLPQASP ISVYLFPGER
  1321  SGAPPPSPPV GGPAGSLGSC SEEKEDEREE EGDGDTLDSD EFCILDAPGL GIPPRDGEPV
  1381  VTQLHPGPIV VRDGYFSRPI GSTDLLRAPA HFPVPSTRVV LREVSLVWHL YGGRDFGPHP
  1441  GHRARTGLSG PRSSPSRCSG PNRPQNSWRT QGGSGRQHHV LMEIQLSKVS FQHEVYPAEP
  1501  ATGPAAPSQE LEERPLSRQV FIVQELEVRD RLASSQINKF LYLHTSERMP RRAHSNMLTI
  1561  KALHVAPTTN LGGPECCLRV SLMPLRLNVD QDALFFLKDF FTSLVAGINP VVPGETSAEA
  1621  RPETRAQPSS PLEGQAEGVE TTGSQEAPGG GHSPSPPDQQ PIYFREFRFT SEVPIWLDYH
  1681  GKHVTMDQVG TFAGLLIGLA QLNCSELKLK RLCCRHGLLG VDKVLGYALN EWLQDIRKNQ
  1741  LPGLLGGVGP MHSVVQLFQG FRDLLWLPIE QYRKDGRLMR GLQRGAASFG SSTASAALEL
  1801  SNRLVQAIQA TAETVYDILS PAAPVSRSLQ DKRSARRLRR GQQPADLREG VAKAYDTVRE
  1861  GILDTAQTIC DVASRGHEQK GLTGAVGGVI RQLPPTVVKP LILATEATSS LLGGMRNQIV
  1921  PDAHKDHALK WRSDSAQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 57 nTPM
liver: 56 nTPM
skin: 34 nTPM
skeletal muscle: 26 nTPM
spleen: 25 nTPM
cerebellum: 25 nTPM

Single-cell type

neutrophils: 362 nCPM
syncytiotrophoblasts: 95 nCPM
monocytes: 58 nCPM
neutrophil progenitors: 51 nCPM
nk-cells: 49 nCPM
t-cells: 48 nCPM

Immune cell

neutrophil: 17 nTPM
basophil: 3 nTPM
gdT-cell: 2.5 nTPM
naive CD8 T-cell: 2.4 nTPM
plasmacytoid DC: 2.4 nTPM
eosinophil: 2.2 nTPM

Brain region

cerebral cortex: 93 nTPM
medulla oblongata: 33 nTPM
pons: 31 nTPM
midbrain: 30 nTPM
choroid plexus: 28 nTPM
thalamus: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.05
gnomAD missense Z: 1.81
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG2A as an antibody target. Whether an autoantibody or antibody against ATG2A could matter depends on whether native ATG2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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