Poly(A) RNA polymerase, mitochondrial-like, central palm domain

Definition

This domain is found in human Poly(A) RNA polymerase, mitochondrial (MTPAP) and similar proteins from eukaryotes. MTPAP is a noncanonical polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. It contains three domains: a N-terminal domain RL ([pfam:PF17797]) and the canonical palm (this entry) and fingers domains. This domain shows a five -stranded beta-sheet with the three catalytic aspartic acid residues located on its surface PMID:21292163, together with several alpha- helices, forming an alpha-beta configuration.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• MTPAP
• TENT2
• TENT4A
• TENT4B
• TUT1
• TUT4
• TUT7