SELENBP1

Protein identityUniProt · HPA

UniProt accession

Q13228

Gene

SELENBP1

Ensembl

ENSG00000143416

Chromosome

1

Canonical length

472 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoli

OverviewNCBI Gene

This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

472 residues, UniProt reviewed canonical sequence.

>Q13228|SELENBP1
     1  MATKCGNCGP GYSTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD PKSPQYCQVI
    61  HRLPMPNLKD ELHHSGWNTC SSCFGDSTKS RTKLVLPSLI SSRIYVVDVG SEPRAPKLHK
   121  VIEPKDIHAK CELAFLHTSH CLASGEVMIS SLGDVKGNGK GGFVLLDGET FEVKGTWERP
   181  GGAAPLGYDF WYQPRHNVMI STEWAAPNVL RDGFNPADVE AGLYGSHLYV WDWQRHEIVQ
   241  TLSLKDGLIP LEIRFLHNPD AAQGFVGCAL SSTIQRFYKN EGGTWSVEKV IQVPPKKVKG
   301  WLLPEMPGLI TDILLSLDDR FLYFSNWLHG DLRQYDISDP QRPRLTGQLF LGGSIVKGGP
   361  VQVLEDEELK SQPEPLVVKG KRVAGGPQMI QLSLDGKRLY ITTSLYSAWD KQFYPDLIRE
   421  GSVMLQVDVD TVKGGLKLNP NFLVDFGKEP LGPALAHELR YPGGDCSSDI WI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SELENBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.19

Highest tissue expression

509 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SELENBP1.

Disease | AllUniProt

Conditions SELENBP1 is implicated in, by any mechanism.

• Extraoral halitosis due to methanethiol oxidase deficiency (EHMTO) MIM:618148

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 123 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Extraoral halitosis due to methanethiol oxidase deficiency
• Extra oral halitosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.29

gnomAD pLI

0

gnomAD missense Z

0.45

DepMap mean gene effect

-0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein transport

Molecular functions

• selenium binding
• methanethiol oxidase activity

Cellular components

• cytosol
• extracellular exosome
• extracellular space
• fibrillar center
• membrane
• nucleolus

Protein domainsUniProt · Pfam · InterPro

• Selenium-binding protein
• 56kDa selenium binding protein (SBP56)

KeywordsUniProt

• Acetylation
• Cytoplasm
• Membrane
• Nucleus
• Oxidoreductase
• Phosphoprotein
• Protein transport
• Selenium
• Transport

InteractionsUniProt · HPA

Protein binding partners of SELENBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• USP33
• MED31
• TRIP13