Seroatlas · Human Serome Atlas

COMT

Catechol O-methyltransferase

Also known as: COMT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P21964
Gene
COMT
Ensembl
ENSG00000093010
Chromosome
22
Canonical length
271 aa
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Vesicles

OverviewNCBI Gene

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>P21964|COMT
     1  MPEAPPLLLA AVLLGLVLLV VLLLLLRHWG WGLCLIGWNE FILQPIHNLL MGDTKEQRIL
    61  NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG
   121  YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY
   181  DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE
   241  CTHYQSFLEY REVVDGLEKA IYKGPGSEAG P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
268 nTPM

Expression across tissuesHPA

Tissue

  • liver: 268 nTPM
  • choroid plexus: 185 nTPM
  • esophagus: 185 nTPM
  • adrenal gland: 170 nTPM
  • spinal cord: 160 nTPM
  • salivary gland: 126 nTPM

Single-cell type

  • cytotrophoblasts: 1,150 nCPM
  • syncytiotrophoblasts: 722 nCPM
  • esophageal suprabasal cells: 668 nCPM
  • esophageal basal cells: 600 nCPM
  • migrating cytotrophoblasts: 462 nCPM
  • melanocytes: 368 nCPM

Immune cell

  • classical monocyte: 313 nTPM
  • plasmacytoid DC: 292 nTPM
  • myeloid DC: 252 nTPM
  • intermediate monocyte: 218 nTPM
  • total PBMC: 179 nTPM
  • non-classical monocyte: 152 nTPM

Brain region

  • white matter: 149 nTPM
  • choroid plexus: 142 nTPM
  • medulla oblongata: 141 nTPM
  • cerebellum: 131 nTPM
  • spinal cord: 120 nTPM
  • midbrain: 119 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about COMT.

Disease | AllUniProt

Conditions COMT is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 209 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.7
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMT as an antibody target. Whether an autoantibody or antibody against COMT could matter depends on whether native COMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMT is annotated at the cell surface, where native COMT is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label COMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/COMT. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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