Seroatlas · Human Serome Atlas

MYOZ1

Myozenin-1

Also known as: CS-2, FATZ, MYOZ, MYOZ1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NP98
Gene: MYOZ1
Ensembl: ENSG00000177791
Chromosome: 10
Canonical length: 299 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9NP98|MYOZ1
     1  MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS LLTNRGSKMF
    61  KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT AGQGFSYSKS NGRGGSQAGG
   121  SGSAGQYGSD QQHHLGSGSG AGGTGGPAGQ AGRGGAAGTA GVGETGSGDQ AGGEGKHITV
   181  FKTYISPWER AMGVDPQQKM ELGIDLLAYG AKAELPKYKS FNRTAMPYGG YEKASKRMTF
   241  QMPKFDLGPL LSEPLVLYNQ NLSNRPSFNR TPIPWLSSGE PVDYNVDIGI PLDGETEEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYOZ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 6,685 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 6,685 nTPM
tongue: 3,089 nTPM
esophagus: 60 nTPM
heart muscle: 51 nTPM
salivary gland: 44 nTPM
blood vessel: 40 nTPM

Single-cell type

thymic myoid cells: 691 nCPM
myonuclei: 381 nCPM
epididymal principal cells: 54 nCPM
vascular smooth muscle cells: 30 nCPM
myosatellite cells: 9.3 nCPM
peritubular myoid cells: 7.4 nCPM

Immune cell

MAIT T-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

hypothalamus: 3.3 nTPM
basal ganglia: 2.5 nTPM
medulla oblongata: 2.4 nTPM
spinal cord: 2.2 nTPM
thalamus: 2.2 nTPM
white matter: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

myofibril assembly
negative regulation of calcineurin-NFAT signaling cascade
negative regulation of transcription by RNA polymerase II
sarcomere organization
skeletal muscle fiber adaptation
skeletal muscle tissue development
wound healing
negative regulation of skeletal muscle tissue regeneration

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYOZ1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYOZ1 as an antibody target. Whether an autoantibody or antibody against MYOZ1 could matter depends on whether native MYOZ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYOZ1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYOZ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...