IL13RA1

Protein identityUniProt · HPA

UniProt accession

P78552

Gene

IL13RA1

Ensembl

ENSG00000131724

Chromosome

X

Canonical length

427 aa

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Secretome location

Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

427 residues, UniProt reviewed canonical sequence.

>P78552|IL13RA1
     1  MEWPARLCGL WALLLCAGGG GGGGGAAPTE TQPPVTNLSV SVENLCTVIW TWNPPEGASS
    61  NCSLWYFSHF GDKQDKKIAP ETRRSIEVPL NERICLQVGS QCSTNESEKP SILVEKCISP
   121  PEGDPESAVT ELQCIWHNLS YMKCSWLPGR NTSPDTNYTL YYWHRSLEKI HQCENIFREG
   181  QYFGCSFDLT KVKDSSFEQH SVQIMVKDNA GKIKPSFNIV PLTSRVKPDP PHIKNLSFHN
   241  DDLYVQWENP QNFISRCLFY EVEVNNSQTE THNVFYVQEA KCENPEFERN VENTSCFMVP
   301  GVLPDTLNTV RIRVKTNKLC YEDDKLWSNW SQEMSIGKKR NSTLYITMLL IVPVIVAGAI
   361  IVLLLYLKRL KIIIFPPIPD PGKIFKEMFG DQNDDTLHWK KYDIYEKQTK EETDSVVLIE
   421  NLKKASQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL13RA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

113 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.32

gnomAD pLI

0.96

gnomAD missense Z

0.52

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway
• cytokine-mediated signaling pathway
• positive regulation of immunoglobulin production

Molecular functions

• cytokine binding
• cytokine receptor activity

Cellular components

• external side of plasma membrane
• plasma membrane
• receptor complex
• interleukin-13 receptor complex

Protein domainsUniProt · Pfam · InterPro

• Short hematopoietin receptor, family 2, conserved site
• Fibronectin type III
• Immunoglobulin-like fold
• Type I cytokine receptor, cytokine-binding domain
• Fibronectin type III superfamily
• Interleukin-6 receptor alpha chain, binding
• Interleukin-13 receptor subunit alpha-1, Ig-like domain
• Interleukin-13 receptor subunit alpha Ig-like domain

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of IL13RA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL4
• TRAF3IP1
• IL13