Seroatlas · Human Serome Atlas

CMTM6

CKLF-like MARVEL transmembrane domain-containing protein 6

Also known as: CKLF6_HUMAN, CKLFSF6, FLJ20396

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX76
Gene: CMTM6
Ensembl: ENSG00000091317
Chromosome: 3
Canonical length: 183 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9NX76|CMTM6
     1  MENGAVYSPT TEEDPGPARG PRSGLAAYFF MGRLPLLRRV LKGLQLLLSL LAFICEEVVS
    61  QCTLCGGLYF FEFVSCSAFL LSLLILIVYC TPFYERVDTT KVKSSDFYIT LGTGCVFLLA
   121  SIIFVSTHDR TSAEIAAIVF GFIASFMFLL DFITMLYEKR QESQLRKPEN TTRAEALTEP
   181  LNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMTM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 166 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 166 nTPM
liver: 124 nTPM
bone marrow: 92 nTPM
urinary bladder: 74 nTPM
tonsil: 73 nTPM
placenta: 66 nTPM

Single-cell type

neutrophils: 1,208 nCPM
breast lactating cells: 1,034 nCPM
neutrophil progenitors: 561 nCPM
platelets: 555 nCPM
cdc: 508 nCPM
megakaryocytes: 488 nCPM

Immune cell

neutrophil: 314 nTPM
non-classical monocyte: 211 nTPM
eosinophil: 208 nTPM
basophil: 177 nTPM
intermediate monocyte: 133 nTPM
total PBMC: 108 nTPM

Brain region

choroid plexus: 39 nTPM
medulla oblongata: 18 nTPM
white matter: 18 nTPM
spinal cord: 18 nTPM
thalamus: 16 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0.43
gnomAD missense Z: 0.5
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CMTM6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMTM6 as an antibody target. Whether an autoantibody or antibody against CMTM6 could matter depends on whether native CMTM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMTM6 is annotated at the cell surface, where native CMTM6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CMTM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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