LEM/LEM-like domain superfamily

Definition

The LEM domain is a ~40-residue motif found in nuclear membrane-associated proteins, including lamino-associated polypeptide 2 (LAP2), emerin, MAN1, otefin and Lem-3 PMID:11792821. Defects in the emerin gene are a cause of Emery-Dreifuss muscular dystrophy, an X-linked disorder characterised by early contractures, muscle wasting, weakness and cardiomyopathy. The N-terminal LEM domain in emerin mediates binding to BAF (barrier-to-autointegration factor). All LAP2 isoforms also share an N-terminal segment composed of a LEM domain that is connected to a highly divergent LEM-like domain by a highly flexible 60-residue linker. The LEM-like globular domain has the same size and structural fold as the LEM domain, but has been shown to bind directly to DNA [[cite:PMID:10671519], [cite:PMID:11500367], [cite:PMID:11435115]].

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• ANKLE1
• ANKLE2
• EMD
• LEMD1
• LEMD2
• LEMD3
• TMPO