BANF1

Protein identityUniProt · HPA

UniProt accession

O75531

Gene

BANF1

Ensembl

ENSG00000175334

Chromosome

11

Canonical length

89 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>O75531|BANF1
     1  MTTSQKHRDF VAEPMGEKPV GSLAGIGEVL GKKLEERGFD KAYVVLGQFL VLKKDEDLFR
    61  EWLKDTCGAN AKQSRDCFGC LREWCDAFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BANF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

546 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BANF1.

Disease | AllUniProt

Conditions BANF1 is implicated in, by any mechanism.

• Nestor-Guillermo progeria syndrome (NGPS) MIM:614008

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.87

gnomAD pLI

0.65

gnomAD missense Z

1.43

DepMap mean gene effect

-2.07

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromatin organization
• chromosome organization
• DNA integration
• mitotic nuclear membrane reassembly
• negative regulation of cGAS/STING signaling pathway
• negative regulation of innate immune response
• negative regulation of protein ADP-ribosylation
• negative regulation of type I interferon production
• negative regulation of viral genome replication
• response to oxidative stress
• response to virus

Molecular functions

• DNA binding
• double-stranded DNA binding
• identical protein binding
• protein homodimerization activity

Cellular components

• chromatin
• condensed chromosome
• cytoplasm
• cytosol
• nuclear envelope
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Barrier- to-autointegration factor, BAF
• Barrier-to-autointegration factor, BAF superfamily
• Barrier-to-autointegration factor
• Barrier to autointegration factor

KeywordsUniProt

• Acetylation
• Chromosome
• Cytoplasm
• DNA-binding
• Host-virus interaction
• Nucleus
• Osteoporosis
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of BANF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANKLE1
• CRX
• LEMD2
• LMNA
• PARP1
• TMPO
• EMD
• HMGA1
• NUMA1