Seroatlas · Human Serome Atlas

HES1

Transcription factor HES-1

Also known as: bHLHb39, FLJ20408, HES-1, HES1_HUMAN, HRY

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14469
Gene: HES1
Ensembl: ENSG00000114315
Chromosome: 3
Canonical length: 280 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

280 residues, UniProt reviewed canonical sequence.

>Q14469|HES1
     1  MPADIMEKNS SSPVAATPAS VNTTPDKPKT ASEHRKSSKP IMEKRRRARI NESLSQLKTL
    61  ILDALKKDSS RHSKLEKADI LEMTVKHLRN LQRAQMTAAL STDPSVLGKY RAGFSECMNE
   121  VTRFLSTCEG VNTEVRTRLL GHLANCMTQI NAMTYPGQPH PALQAPPPPP PGPGGPQHAP
   181  FAPPPPLVPI PGGAAPPPGG APCKLGSQAG EAAKVFGGFQ VVPAPDGQFA FLIPNGAFAH
   241  SGPVIPVYTS NSGTSVGPNA VSPSSGPSLT ADSMWRPWRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HES1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 176 nTPM

Expression across tissuesHPA

Tissue

skin: 176 nTPM
vagina: 130 nTPM
esophagus: 122 nTPM
cervix: 116 nTPM
kidney: 99 nTPM
thyroid gland: 89 nTPM

Single-cell type

granulosa cells: 1,612 nCPM
enteric stem cells: 1,531 nCPM
prostatic hillock cells: 1,246 nCPM
epididymal basal cells: 1,238 nCPM
prostatic club cells: 1,127 nCPM
esophageal apical cells: 1,122 nCPM

Immune cell

eosinophil: 16 nTPM
non-classical monocyte: 2 nTPM
intermediate monocyte: 1.9 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

midbrain: 26 nTPM
hypothalamus: 25 nTPM
medulla oblongata: 22 nTPM
basal ganglia: 20 nTPM
thalamus: 20 nTPM
hippocampal formation: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.71
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HES1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HES1 as an antibody target. Whether an autoantibody or antibody against HES1 could matter depends on whether native HES1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HES1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HES1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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