Seroatlas · Human Serome Atlas

VENTX

Homeobox protein VENTX

Also known as: HPX42B, VENTX_HUMAN, VENTX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95231
Gene: VENTX
Ensembl: ENSG00000151650
Chromosome: 10
Canonical length: 258 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>O95231|VENTX
     1  MRLSSSPPRG PQQLSSFGSV DWLSQSSCSG PTHTPRPADF SLGSLPGPGQ TSGAREPPQA
    61  VSIKEAAGSS NLPAPERTMA GLSKEPNTLR APRVRTAFTM EQVRTLEGVF QHHQYLSPLE
   121  RKRLAREMQL SEVQIKTWFQ NRRMKHKRQM QDPQLHSPFS GSLHAPPAFY STSSGLANGL
   181  QLLCPWAPLS GPQALMLPPG SFWGLCQVAQ EALASAGASC CGQPLASHPP TPGRPSLGPA
   241  LSTGPRGLCA MPQTGDAF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VENTX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

spleen: 5.7 nTPM
adipose tissue: 4.7 nTPM
blood vessel: 4.1 nTPM
lung: 3.7 nTPM
appendix: 3.4 nTPM
bone marrow: 2.5 nTPM

Single-cell type

monocytes: 15 nCPM
macrophages: 15 nCPM
cdc: 12 nCPM
microglia: 5.9 nCPM
neutrophils: 2.5 nCPM
conjunctival goblet cells: 1 nCPM

Immune cell

intermediate monocyte: 3.2 nTPM
classical monocyte: 2.6 nTPM
non-classical monocyte: 2.4 nTPM
myeloid DC: 1.8 nTPM
basophil: 1.7 nTPM
neutrophil: 0.9 nTPM

Brain region

thalamus: 7.3 nTPM
medulla oblongata: 6.2 nTPM
choroid plexus: 6.1 nTPM
midbrain: 5.7 nTPM
white matter: 5.6 nTPM
cerebral cortex: 5.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.67
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VENTX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TLE1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VENTX as an antibody target. Whether an autoantibody or antibody against VENTX could matter depends on whether native VENTX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VENTX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VENTX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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