Seroatlas · Human Serome Atlas

ZNF212

Zinc finger protein 212

Also known as: C2H2-150, ZN212_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UDV6
Gene: ZNF212
Ensembl: ENSG00000170260
Chromosome: 7
Canonical length: 495 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

495 residues, UniProt reviewed canonical sequence.

>Q9UDV6|ZNF212
     1  MAESAPARHR RKRRSTPLTS STLPSQATEK SSYFQTTEIS LWTVVAAIQA VEKKMESQAA
    61  RLQSLEGRTG TAEKKLADCE KMAVEFGNQL EGKWAVLGTL LQEYGLLQRR LENVENLLRN
   121  RNFWILRLPP GSKGEAPKVS RSLENDGVCF TEQEWENLED WQKELYRNVM ESNYETLVSL
   181  KVLGQTEGEA ELGTEMLGDL EEEGPGGAHP AGGVMIKQEL QYTQEGPADL PGEFSCIAEE
   241  QAFLSPEQTE LWGGQGSSVL LETGPGDSTL EEPVGSRVPS SSRTVGCPKQ KSHRQVQLDQ
   301  ECGQGLKLKK DTSRPYECSE CEITFRYKQQ LATHLRSHSG WGSCTPEEPE ESLRPRPRLK
   361  PQTKKAKLHQ CDVCLRSFSC KVSLVTHQRC HLQEGPSAGQ HVQERFSPNS LVALPGHIPW
   421  RKSRSSLICG YCGKSFSHPS DLVRHQRIHT GERPYSCTEC EKSFVQKQHL LQHQKIHQRE
   481  RGGLALEPGR PNGLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF212 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

esophagus: 14 nTPM
testis: 12 nTPM
bone marrow: 12 nTPM
skin: 10 nTPM
spleen: 10 nTPM
liver: 10 nTPM

Single-cell type

esophageal apical cells: 111 nCPM
syncytiotrophoblasts: 47 nCPM
differentiating spermatogonia: 39 nCPM
endometrial glandular cells: 33 nCPM
endometrial ciliated cells: 31 nCPM
myonuclei: 30 nCPM

Immune cell

NK-cell: 8.3 nTPM
eosinophil: 7.6 nTPM
naive CD4 T-cell: 6.4 nTPM
T-reg: 6 nTPM
naive CD8 T-cell: 5.6 nTPM
gdT-cell: 5 nTPM

Brain region

medulla oblongata: 8.9 nTPM
cerebellum: 8.8 nTPM
white matter: 8.7 nTPM
pons: 8.5 nTPM
basal ganglia: 8.2 nTPM
midbrain: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF212 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF212 as an antibody target. Whether an autoantibody or antibody against ZNF212 could matter depends on whether native ZNF212 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF212 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF212 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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