Seroatlas · Human Serome Atlas

SDF4

45 kDa calcium-binding protein

Also known as: CAB45_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRK5
Gene: SDF4
Canonical length: 362 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SDF4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>Q9BRK5|SDF4
     1  MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN REENEILPPD
    61  HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR RKLMVIFSKV DVNTDRKISA
   121  KEMQRWIMEK TAEHFQEAME ESKTHFRAVD PDGDGHVSWD EYKVKFLASK GHSEKEVADA
   181  IRLNEELKVD EETQEVLENL KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE
   241  IVRDLDQDGD KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA
   301  EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK LVDYARSVHE
   361  EF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SDF4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

liver: 143 nTPM
blood vessel: 130 nTPM
heart muscle: 124 nTPM
duodenum: 110 nTPM
small intestine: 110 nTPM
pancreas: 96 nTPM

Single-cell type

extravillous trophoblasts: 382 nCPM
enterocytes: 303 nCPM
colonocytes: 188 nCPM
syncytiotrophoblasts: 163 nCPM
plasma cells: 140 nCPM
migrating cytotrophoblasts: 133 nCPM

Immune cell

eosinophil: 31 nTPM
memory CD8 T-cell: 28 nTPM
memory CD4 T-cell: 28 nTPM
NK-cell: 27 nTPM
T-reg: 25 nTPM
non-classical monocyte: 23 nTPM

Brain region

choroid plexus: 129 nTPM
medulla oblongata: 85 nTPM
thalamus: 84 nTPM
cerebral cortex: 75 nTPM
pons: 74 nTPM
cerebellum: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.01
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SDF4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SDF4 as an antibody target. Whether an autoantibody or antibody against SDF4 could matter depends on whether native SDF4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SDF4 is annotated at the cell surface, where native SDF4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SDF4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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