Seroatlas · Human Serome Atlas

BCL10

B-cell lymphoma/leukemia 10

Also known as: BCL10_HUMAN, c-E10, CARMEN, CIPER, CLAP, mE10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95999
Gene
BCL10
Ensembl
ENSG00000142867
Chromosome
1
Canonical length
233 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homomultimer

OverviewNCBI Gene

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>O95999|BCL10
     1  MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS
    61  SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT DEVLKLRNIK LEHLKGLKCS
   121  SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS TVMYHPEGES STTPFFSTNS SLNLPVLEVG
   181  RTENTIFSST TLPRPGDPGA PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • colon: 26 nTPM
  • rectum: 23 nTPM
  • urinary bladder: 22 nTPM
  • bone marrow: 21 nTPM
  • gallbladder: 19 nTPM
  • esophagus: 19 nTPM

Single-cell type

  • esophageal apical cells: 406 nCPM
  • ocular epithelial cells: 249 nCPM
  • urothelial cells: 224 nCPM
  • fallopian secretory cells: 216 nCPM
  • endometrial secretory cells: 214 nCPM
  • basal keratinocytes: 214 nCPM

Immune cell

  • neutrophil: 66 nTPM
  • basophil: 59 nTPM
  • memory B-cell: 39 nTPM
  • eosinophil: 37 nTPM
  • intermediate monocyte: 35 nTPM
  • naive B-cell: 34 nTPM

Brain region

  • cerebral cortex: 12 nTPM
  • choroid plexus: 11 nTPM
  • thalamus: 11 nTPM
  • cerebellum: 9.6 nTPM
  • white matter: 9.5 nTPM
  • hippocampal formation: 9.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BCL10.

Disease | AllUniProt

Conditions BCL10 is implicated in, by any mechanism.

  • Immunodeficiency 37 (IMD37) MIM:616098
  • Lymphoma, mucosa-associated lymphoid type (MALTOMA) MIM:137245

Disease | GeneticClinVar

20 pathogenic / likely-pathogenic of 143 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Follicular lymphoma
  • Immunodeficiency 37
  • Mucosa-associated lymphoma
  • MALE GERM CELL TUMOR, SOMATIC
  • Mesothelioma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0.34
gnomAD missense Z
1.39
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL10 as an antibody target. Whether an autoantibody or antibody against BCL10 could matter depends on whether native BCL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL10 is annotated at the cell surface, where native BCL10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BCL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCL10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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