Seroatlas · Human Serome Atlas

CD37

Leukocyte antigen CD37

Also known as: CD37_HUMAN, TSPAN26

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11049
Gene
CD37
Ensembl
ENSG00000104894
Chromosome
19
Canonical length
281 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>P11049|CD37
     1  MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV
    61  LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR
   121  DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS
   181  CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN
   241  NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
233 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 233 nTPM
  • lymph node: 201 nTPM
  • bone marrow: 147 nTPM
  • small intestine: 112 nTPM
  • appendix: 95 nTPM
  • tonsil: 83 nTPM

Single-cell type

  • b-cells: 991 nCPM
  • hofbauer cells: 452 nCPM
  • mast cells: 396 nCPM
  • pdcs: 358 nCPM
  • neutrophils: 357 nCPM
  • late spermatids: 351 nCPM

Immune cell

  • naive B-cell: 1,729 nTPM
  • memory B-cell: 1,518 nTPM
  • neutrophil: 907 nTPM
  • eosinophil: 831 nTPM
  • total PBMC: 816 nTPM
  • non-classical monocyte: 752 nTPM

Brain region

  • white matter: 55 nTPM
  • spinal cord: 30 nTPM
  • medulla oblongata: 30 nTPM
  • thalamus: 28 nTPM
  • pons: 26 nTPM
  • hypothalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
0.72
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD37 as an antibody target. Whether an autoantibody or antibody against CD37 could matter depends on whether native CD37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD37 is annotated at the cell surface, where native CD37 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD37. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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