Seroatlas · Human Serome Atlas

TFRC

Transferrin receptor protein 1

Also known as: CD71, p90, TFR1, TFR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P02786
Gene
TFRC
Ensembl
ENSG00000072274
Chromosome
3
Canonical length
760 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Subcellular location
Endosomes,Lysosomes
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

760 residues, UniProt reviewed canonical sequence.

>P02786|TFRC
     1  MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AVDEEENADN NTKANVTKPK
    61  RCSGSICYGT IAVIVFFLIG FMIGYLGYCK GVEPKTECER LAGTESPVRE EPGEDFPAAR
   121  RLYWDDLKRK LSEKLDSTDF TGTIKLLNEN SYVPREAGSQ KDENLALYVE NQFREFKLSK
   181  VWRDQHFVKI QVKDSAQNSV IIVDKNGRLV YLVENPGGYV AYSKAATVTG KLVHANFGTK
   241  KDFEDLYTPV NGSIVIVRAG KITFAEKVAN AESLNAIGVL IYMDQTKFPI VNAELSFFGH
   301  AHLGTGDPYT PGFPSFNHTQ FPPSRSSGLP NIPVQTISRA AAEKLFGNME GDCPSDWKTD
   361  STCRMVTSES KNVKLTVSNV LKEIKILNIF GVIKGFVEPD HYVVVGAQRD AWGPGAAKSG
   421  VGTALLLKLA QMFSDMVLKD GFQPSRSIIF ASWSAGDFGS VGATEWLEGY LSSLHLKAFT
   481  YINLDKAVLG TSNFKVSASP LLYTLIEKTM QNVKHPVTGQ FLYQDSNWAS KVEKLTLDNA
   541  AFPFLAYSGI PAVSFCFCED TDYPYLGTTM DTYKELIERI PELNKVARAA AEVAGQFVIK
   601  LTHDVELNLD YERYNSQLLS FVRDLNQYRA DIKEMGLSLQ WLYSARGDFF RATSRLTTDF
   661  GNAEKTDRFV MKKLNDRVMR VEYHFLSPYV SPKESPFRHV FWGSGSHTLP ALLENLKLRK
   721  QNNGAFNETL FRNQLALATW TIQGAANALS GDVWDIDNEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TFRC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
99 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 99 nTPM
  • ovary: 87 nTPM
  • placenta: 83 nTPM
  • lung: 68 nTPM
  • skeletal muscle: 65 nTPM
  • tongue: 63 nTPM

Single-cell type

  • erythrocyte progenitors: 1,608 nCPM
  • syncytiotrophoblasts: 710 nCPM
  • monocytes: 410 nCPM
  • macrophages: 398 nCPM
  • erythrocytes: 278 nCPM
  • megakaryocyte-erythroid progenitors: 269 nCPM

Immune cell

  • non-classical monocyte: 9.2 nTPM
  • intermediate monocyte: 5.9 nTPM
  • plasmacytoid DC: 3.9 nTPM
  • T-reg: 3.8 nTPM
  • memory B-cell: 2.9 nTPM
  • myeloid DC: 2.2 nTPM

Brain region

  • pons: 24 nTPM
  • cerebral cortex: 22 nTPM
  • thalamus: 21 nTPM
  • medulla oblongata: 20 nTPM
  • hippocampal formation: 17 nTPM
  • amygdala: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TFRC.

Disease | AllUniProt

Conditions TFRC is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 727 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • TFRC-related combined immunodeficiency

Disease | ImmuneIEDB

Conditions an epitope on TFRC was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.58
gnomAD pLI
0
gnomAD missense Z
0.6
DepMap mean gene effect
-0.79
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TFRC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TFRC as an antibody target. Whether an autoantibody or antibody against TFRC could matter depends on whether native TFRC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TFRC is annotated at the cell surface, where native TFRC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TFRC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TFRC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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