TMSB4X
Thymosin beta-4
Also known as: TB4X, TMSB4, TYB4_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P62328
- Gene
- TMSB4X
- Ensembl
- ENSG00000205542
- Chromosome
- X
- Canonical length
- 44 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles,Cytosol
OverviewNCBI Gene
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
44 residues, UniProt reviewed canonical sequence.
>P62328|TMSB4X
1 MSDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMSB4X can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.61
- Highest tissue expression
- 10,459 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 10,459 nTPM
- lymph node: 9,761 nTPM
- bone marrow: 8,229 nTPM
- spleen: 7,469 nTPM
- tonsil: 6,765 nTPM
- lung: 6,098 nTPM
Single-cell type
- megakaryocytes: 73,790 nCPM
- platelets: 38,486 nCPM
- hofbauer cells: 36,356 nCPM
- kupffer cells: 30,347 nCPM
- decidual stromal cells: 27,198 nCPM
- cdc: 22,882 nCPM
Immune cell
- total PBMC: 86,915 nTPM
- eosinophil: 51,158 nTPM
- basophil: 43,123 nTPM
- non-classical monocyte: 37,735 nTPM
- neutrophil: 36,081 nTPM
- classical monocyte: 34,835 nTPM
Brain region
- white matter: 3,967 nTPM
- spinal cord: 3,610 nTPM
- medulla oblongata: 3,474 nTPM
- basal ganglia: 2,562 nTPM
- pons: 2,558 nTPM
- thalamus: 2,274 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.67
- gnomAD pLI
- 0.41
- gnomAD missense Z
- 0.98
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
OntologyGO
Biological processes
- actin filament organization
- negative regulation of actin filament polymerization
- negative regulation of canonical NF-kappaB signal transduction
- negative regulation of inflammatory response
- positive regulation of ATP biosynthetic process
- positive regulation of blood vessel endothelial cell migration
- positive regulation of endothelial cell chemotaxis
- regulation of cell migration
- tumor necrosis factor-mediated signaling pathway
Molecular functions
- actin monomer binding
- enzyme binding
- protein sequestering activity
- RNA binding
- actin monomer sequestering activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of TMSB4X in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMSB4X as an antibody target. Whether an autoantibody or antibody against TMSB4X could matter depends on whether native TMSB4X is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMSB4X is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMSB4X as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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