PRTN3

Protein identityUniProt · HPA

UniProt accession

P24158

Gene

PRTN3

Ensembl

ENSG00000196415

Chromosome

19

Canonical length

256 aa

Protein class

Candidate cardiovascular disease genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Vesicles,Cytosol

Secretome location

Secreted to blood

OverviewNCBI Gene

Enables enzyme binding activity; serine-type endopeptidase activity; and signaling receptor binding activity. Involved in several processes, including mature conventional dendritic cell differentiation; neutrophil extravasation; and positive regulation of GTPase activity. Located in azurophil granule lumen; cytosol; and plasma membrane raft. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>P24158|PRTN3
     1  MAHRPPSPAL ASVLLALLLS GAARAAEIVG GHEAQPHSRP YMASLQMRGN PGSHFCGGTL
    61  IHPSFVLTAA HCLRDIPQRL VNVVLGAHNV RTQEPTQQHF SVAQVFLNNY DAENKLNDVL
   121  LIQLSSPANL SASVATVQLP QQDQPVPHGT QCLAMGWGRV GAHDPPAQVL QELNVTVVTF
   181  FCRPHNICTF VPRRKAGICF GDSGGPLICD GIIQGIDSFV IWGCATRLFP DFFTRVALYV
   241  DWIRSTLRRV EAKGRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRTN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.28

Highest tissue expression

1,978 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRTN3.

Disease | ImmuneIEDB

Conditions an epitope on PRTN3 was assayed in.

• granulomatosis with polyangiitis B and T cell
• systemic scleroderma B cell
• autoimmune vasculitis B cell
• Goodpasture syndrome B cell
• systemic lupus erythematosus B cell
• chronic myeloid leukemia T cell
• acute myeloid leukemia T cell
• viral infectious disease T cell
• multiple myeloma T cell
• chronic myelogenous leukemia T cell
• leukemia T cell
• acute lymphoblastic leukemia T cell
• cancer T cell
• acute myeloid leukemia with minimal differentiation T cell

Disease | AutoantibodyPubMed

Conditions in which antibodies against PRTN3 are reported. Each links to that disease's full target list.

• Granulomatosis with Polyangiitis 219
• Vasculitis 93
• Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 86
• Glomerulonephritis 54
• Colitis, Ulcerative 25
• Crohn Disease 11
• Lupus Erythematosus, Systemic 11
• Arthritis, Rheumatoid 10
• Inflammatory Bowel Diseases 9
• Kidney Diseases 9
• Kidney Failure, Chronic 9
• Sjogren's Syndrome 8
• Anti-Glomerular Basement Membrane Disease 7
• Graves Disease 6
• Mixed Connective Tissue Disease 6
• Acute Kidney Injury 5
• Lung Diseases, Interstitial 5
• COVID-19 4
• Glomerulonephritis, IGA 4
• Lupus Nephritis 4

Showing 20 of 52 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for PRTN3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.65

gnomAD pLI

0

gnomAD missense Z

0.15

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antimicrobial humoral response
• cell-cell junction maintenance
• collagen catabolic process
• mature conventional dendritic cell differentiation
• membrane protein ectodomain proteolysis
• negative regulation of phagocytosis
• neutrophil extravasation
• positive regulation of cell population proliferation
• positive regulation of GTPase activity
• proteolysis

Molecular functions

• enzyme binding
• serine-type endopeptidase activity
• serine-type peptidase activity
• signaling receptor binding

Cellular components

• azurophil granule lumen
• cytosol
• extracellular exosome
• extracellular region
• extracellular space
• plasma membrane
• plasma membrane raft

Protein domainsUniProt · Pfam · InterPro

• Serine proteases, trypsin domain
• Peptidase S1A, chymotrypsin family
• Peptidase S1, PA clan
• Serine proteases, trypsin family, histidine active site
• Serine proteases, trypsin family, serine active site
• Peptidase S1 family, Elastase subfamily
• Trypsin

KeywordsUniProt

• Cell membrane
• Collagen degradation
• Disulfide bond
• Glycoprotein
• Hydrolase
• Membrane
• Protease
• Secreted
• Serine protease
• Signal
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of PRTN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ADGRG3
• CD177
• SERPINB1