Seroatlas · Human Serome Atlas

TAF3

Transcription initiation factor TFIID subunit 3

Also known as: TAF140, TAF3_HUMAN, TAFII140

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VWG9
Gene: TAF3
Ensembl: ENSG00000165632
Chromosome: 10
Canonical length: 929 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]

Canonical amino-acid sequenceUniProt

929 residues, UniProt reviewed canonical sequence.

>Q5VWG9|TAF3
     1  MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH RYSELYGRTD
    61  PILDDVGEAF QLMGVSLHEL EDYIHNIEPV TFPHQIPSFP VSKNNVLQFP QPGSKDAEER
   121  KEYIPDYLPP IVSSQEEEEE EQVPTDGGTS AEAMQVPLEE DDELEEEEII NDENFLGKRP
   181  LDSPEAEELP AMKRPRLLST KGDTLDVVLL EAREPLSSIN TQKIPPMLSP VHVQDSTDLA
   241  PPSPEPPMLA PVAKSQMPTA KPLETKSFTP KTKTKTSSPG QKTKSPKTAQ SPAMVGSPIR
   301  SPKTVSKEKK SPGRSKSPKS PKSPKVTTHI PQTPVRPETP NRTPSATLSE KISKETIQVK
   361  QIQTPPDAGK LNSENQPKKA VVADKTIEAS IDAVIARACA EREPDPFEFS SGSESEGDIF
   421  TSPKRISGPE CTTPKASTSA NNFTKSGSTP LPLSGGTSSS DNSWTMDASI DEVVRKAKLG
   481  TPSNMPPNFP YISSPSVSPP TPEPLHKVYE EKTKLPSSVE VKKKLKKELK TKMKKKEKQR
   541  DREREKDKNK DKSKEKDKVK EKEKDKETGR ETKYPWKEFL KEEEADPYKF KIKEFEDVDP
   601  KVKLKDGLVR KEKEKHKDKK KDREKGKKDK DKREKEKVKD KGREDKMKAP APPLVLPPKE
   661  LALPLFSPAT ASRVPAMLPS LLPVLPEKLF EEKEKVKEKE KKKDKKEKKK KKEKEKEKKE
   721  KEREKEKRER EKREKEKEKH KHEKIKVEPV ALAPSPVIPR LTLRVGAGQD KIVISKVVPA
   781  PEAKPAPSQN RPKTPPPAPA PAPGPMLVSP APVPLPLLAQ AAAGPALLPS PGPAASGASA
   841  KAPVRSVVTE TVSTYVIRDE WGNQIWICPG CNKPDDGSPM IGCDDCDDWY HWPCVGIMTA
   901  PPEEMQWFCP KCANKKKDKK HKKRKHRAH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 9.4 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.4 nTPM
tongue: 7 nTPM
testis: 6.9 nTPM
thymus: 6.4 nTPM
blood vessel: 6.3 nTPM
cerebellum: 5.8 nTPM

Single-cell type

sertoli cells: 430 nCPM
myonuclei: 193 nCPM
podocytes: 184 nCPM
b-cells: 167 nCPM
somatotrophs: 164 nCPM
t-cells: 163 nCPM

Immune cell

MAIT T-cell: 2.8 nTPM
memory CD8 T-cell: 1.6 nTPM
naive CD4 T-cell: 1.5 nTPM
gdT-cell: 1.4 nTPM
NK-cell: 1.3 nTPM
memory CD4 T-cell: 1.2 nTPM

Brain region

midbrain: 14 nTPM
cerebellum: 14 nTPM
thalamus: 13 nTPM
medulla oblongata: 12 nTPM
pons: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 2.21
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF3 as an antibody target. Whether an autoantibody or antibody against TAF3 could matter depends on whether native TAF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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