Seroatlas · Human Serome Atlas

RPP30

Ribonuclease P protein subunit p30

Also known as: RPP30_HUMAN, TSG15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78346
Gene: RPP30
Ensembl: ENSG00000148688
Chromosome: 10
Canonical length: 268 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Microtubule ends,Cytosol

OverviewNCBI Gene

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

268 residues, UniProt reviewed canonical sequence.

>P78346|RPP30
     1  MAVFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKQEIEK PVAVSELFTT
    61  LPIVQGKSRP IKILTRLTII VSDPSHCNVL RATSSRARLY DVVAVFPKTE KLFHIACTHL
   121  DVDLVCITVT EKLPFYFKRP PINVAIDRGL AFELVYSPAI KDSTMRRYTI SSALNLMQIC
   181  KGKNVIISSA AERPLEIRGP YDVANLGLLF GLSESDAKAA VSTNCRAALL HGETRKTAFG
   241  IISTVKKPRP SEGDEDCLPA SKKAKCEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPP30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 30 nTPM
testis: 27 nTPM
bone marrow: 24 nTPM
parathyroid gland: 22 nTPM
heart muscle: 22 nTPM
tonsil: 21 nTPM

Single-cell type

oocytes: 299 nCPM
late primary spermatocytes: 160 nCPM
extravillous trophoblasts: 86 nCPM
migrating cytotrophoblasts: 83 nCPM
hofbauer cells: 83 nCPM
early spermatids: 82 nCPM

Immune cell

myeloid DC: 35 nTPM
T-reg: 33 nTPM
plasmacytoid DC: 33 nTPM
memory B-cell: 32 nTPM
intermediate monocyte: 31 nTPM
classical monocyte: 30 nTPM

Brain region

white matter: 22 nTPM
basal ganglia: 19 nTPM
cerebral cortex: 19 nTPM
hypothalamus: 18 nTPM
spinal cord: 18 nTPM
cerebellum: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -0.76
DepMap mean gene effect: -0.95
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RNase P subunit p30
Polymerase/histidinol phosphatase-like
RNase P subunit p30

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPP30 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPP30 as an antibody target. Whether an autoantibody or antibody against RPP30 could matter depends on whether native RPP30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPP30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPP30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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