Seroatlas · Human Serome Atlas

RPP14

Ribonuclease P protein subunit p14

Also known as: P14, RPP14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95059
Gene: RPP14
Ensembl: ENSG00000163684
Chromosome: 3
Canonical length: 124 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>O95059|RPP14
     1  MPAPAATYER VVYKNPSEYH YMKVCLEFQD CGVGLNAAQF KQLLISAVKD LFGEVDAALP
    61  LDILTYEEKT LSAILRICSS GLVKLWSSLT LLGSYKGKKC AFRVIQVSPF LLALSGNSRE
   121  LVLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPP14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 38 nTPM
tongue: 36 nTPM
liver: 11 nTPM
kidney: 8.5 nTPM
heart muscle: 7.9 nTPM
parathyroid gland: 7.2 nTPM

Single-cell type

myonuclei: 11 nCPM
thymic myoid cells: 11 nCPM
distal convoluted tubule cells: 11 nCPM
parietal cells: 8.8 nCPM
proximal tubule cells: 8.7 nCPM
loop of henle epithelial cells: 8.2 nCPM

Immune cell

non-classical monocyte: 6.1 nTPM
NK-cell: 5.6 nTPM
neutrophil: 4.2 nTPM
myeloid DC: 3.9 nTPM
plasmacytoid DC: 3.9 nTPM
classical monocyte: 3.5 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 12 nTPM
white matter: 10 nTPM
hippocampal formation: 10 nTPM
basal ganglia: 9.9 nTPM
hypothalamus: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.91
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

tRNA 5'-leader removal

Molecular functions

ribonuclease P RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPP14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPP14 as an antibody target. Whether an autoantibody or antibody against RPP14 could matter depends on whether native RPP14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPP14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPP14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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