RPP25

Protein identityUniProt · HPA

UniProt accession

Q9BUL9

Gene

RPP25

Ensembl

ENSG00000178718

Chromosome

15

Canonical length

199 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in centriolar satellite and nucleoplasm. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. Biomarker of autistic disorder. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q9BUL9|RPP25
     1  MENFRKVRSE EAPAGCGAEG GGPGSGPFAD LAPGAVHMRV KEGSKIRNLM AFATASMAQP
    61  ATRAIVFSGC GRATTKTVTC AEILKRRLAG LHQVTRLRYR SVREVWQSLP PGPTQGQTPG
   121  EPAASLSVLK NVPGLAILLS KDALDPRQPG YQPPNPHPGP SSPPAAPASK RSLGEPAAGE
   181  GSAKRSQPEP GVADEDQTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPP25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

22 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for RPP25 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.5

gnomAD pLI

0.21

gnomAD missense Z

0.72

DepMap mean gene effect

0.12

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• rRNA processing
• tRNA 5'-leader removal

Molecular functions

• ribonuclease P RNA binding
• RNA binding

Cellular components

• centriolar satellite
• multimeric ribonuclease P complex
• nucleolus
• nucleoplasm
• ribonuclease MRP complex

Protein domainsUniProt · Pfam · InterPro

• DNA/RNA-binding protein Alba-like
• Alba-like domain superfamily
• Alba-like nucleic acid-binding
• Alba

KeywordsUniProt

• Nucleus
• Phosphoprotein
• RNA-binding
• rRNA processing
• tRNA processing

InteractionsUniProt · HPA

Protein binding partners of RPP25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• POP1
• POP4
• POP5
• POP7
• RPP30
• RPP38