Seroatlas · Human Serome Atlas

POP4

Ribonuclease P protein subunit p29

Also known as: RPP29, RPP29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95707
Gene
POP4
Ensembl
ENSG00000105171
Chromosome
19
Canonical length
220 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>O95707|POP4
     1  MKSVIYHALS QKEANDSDVQ PSGAQRAEAF VRAFLKRSTP RMSPQAREDQ LQRKAVVLEY
    61  FTRHKRKEKK KKAKGLSARQ RRELRLFDIK PEQQRYSLFL PLHELWKQYI RDLCSGLKPD
   121  TQPQMIQAKL LKADLHGAII SVTKSKCPSY VGITGILLQE TKHIFKIITK EDRLKVIPKL
   181  NCVFTVETDG FISYIYGSKF QLRSSERSAK KFKAKGTIDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 13 nTPM
  • kidney: 11 nTPM
  • blood vessel: 10 nTPM
  • heart muscle: 10 nTPM
  • adrenal gland: 10 nTPM
  • adipose tissue: 9.8 nTPM

Single-cell type

  • gastric progenitor cells: 147 nCPM
  • late primary spermatocytes: 122 nCPM
  • oocytes: 97 nCPM
  • esophageal apical cells: 86 nCPM
  • esophageal suprabasal cells: 80 nCPM
  • hofbauer cells: 78 nCPM

Immune cell

  • basophil: 73 nTPM
  • T-reg: 53 nTPM
  • intermediate monocyte: 52 nTPM
  • memory B-cell: 48 nTPM
  • total PBMC: 46 nTPM
  • non-classical monocyte: 43 nTPM

Brain region

  • white matter: 13 nTPM
  • medulla oblongata: 12 nTPM
  • cerebellum: 12 nTPM
  • pons: 12 nTPM
  • spinal cord: 12 nTPM
  • hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
-0.96
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ribonuclease P protein subunit Rpp29/RNP1
  • Ribonuclease P/MRP subunit Rpp29
  • Rof/RNase P-like
  • Ribonuclease P/MRP subunit Rpp29 superfamily
  • Ribonuclease P/MRP, subunit p29

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POP4 as an antibody target. Whether an autoantibody or antibody against POP4 could matter depends on whether native POP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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