POP5
Ribonuclease P/MRP protein subunit POP5
Also known as: POP5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q969H6
- Gene
- POP5
- Ensembl
- ENSG00000167272
- Chromosome
- 12
- Canonical length
- 163 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
163 residues, UniProt reviewed canonical sequence.
>Q969H6|POP5
1 MVRFKHRYLL CELVSDDPRC RLSLDDRVLS SLVRDTIARV HGTFGAAACS IGFAVRYLNA
61 YTGIVLLRCR KEFYQLVWSA LPFITYLENK GHRYPCFFNT LHVGGTIRTC QKFLIQYNRR
121 QLLILLQNCT DEGEREAIQK SVTRSCLLEE EEESGEEAAE AMELocalizationUniProt · AlphaFold · HPA
Whether an antibody against POP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 13 nTPM
- adrenal gland: 12 nTPM
- choroid plexus: 10 nTPM
- lymph node: 10 nTPM
- bone marrow: 8.9 nTPM
- kidney: 8.7 nTPM
Single-cell type
- gastric progenitor cells: 96 nCPM
- esophageal basal cells: 90 nCPM
- esophageal suprabasal cells: 79 nCPM
- hofbauer cells: 67 nCPM
- hepatocytes: 67 nCPM
- cytotrophoblasts: 65 nCPM
Immune cell
- plasmacytoid DC: 27 nTPM
- memory B-cell: 25 nTPM
- total PBMC: 21 nTPM
- naive B-cell: 18 nTPM
- gdT-cell: 18 nTPM
- naive CD4 T-cell: 18 nTPM
Brain region
- white matter: 7.6 nTPM
- medulla oblongata: 7.5 nTPM
- spinal cord: 7.3 nTPM
- choroid plexus: 7 nTPM
- basal ganglia: 6.8 nTPM
- hypothalamus: 6.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.6
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.53
- DepMap mean gene effect
- -1.62
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- RNase P subunit Pop5/Rpp14/Rnp2-like
- RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily
- Rpp14/Pop5 family
- Ribonuclease P/MRP protein subunit Pop5
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of POP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads POP5 as an antibody target. Whether an autoantibody or antibody against POP5 could matter depends on whether native POP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
POP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label POP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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