POP7
Ribonuclease P protein subunit p20
Also known as: POP7_HUMAN, RPP2, RPP20
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75817
- Gene
- POP7
- Ensembl
- ENSG00000172336
- Chromosome
- 7
- Canonical length
- 140 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Vesicles
OverviewNCBI Gene
Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
140 residues, UniProt reviewed canonical sequence.
>O75817|POP7
1 MAENREPRGA VEAELDPVEY TLRKRLPSRL PRRPNDIYVN MKTDFKAQLA RCQKLLDGGA
61 RGQNACSEIY IHGLGLAINR AINIALQLQA GSFGSLQVAA NTSTVELVDE LEPETDTREP
121 LTRIRNNSAI HIRVFRVTPKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against POP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.41
- Highest tissue expression
- 70 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 70 nTPM
- liver: 69 nTPM
- cerebral cortex: 59 nTPM
- cerebellum: 53 nTPM
- skin: 52 nTPM
- basal ganglia: 44 nTPM
Single-cell type
- extravillous trophoblasts: 205 nCPM
- migrating cytotrophoblasts: 189 nCPM
- gastric progenitor cells: 181 nCPM
- cytotrophoblasts: 169 nCPM
- syncytiotrophoblasts: 153 nCPM
- esophageal apical cells: 150 nCPM
Immune cell
- basophil: 107 nTPM
- NK-cell: 79 nTPM
- eosinophil: 73 nTPM
- non-classical monocyte: 71 nTPM
- T-reg: 70 nTPM
- intermediate monocyte: 65 nTPM
Brain region
- cerebral cortex: 43 nTPM
- white matter: 38 nTPM
- cerebellum: 38 nTPM
- basal ganglia: 34 nTPM
- hypothalamus: 33 nTPM
- pons: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.78
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 0.46
- DepMap mean gene effect
- -0.78
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Alba-like domain superfamily
- Ribonucleases P/MRP protein subunit Rpp20/Pop7
- Rpp20 subunit of nuclear RNase MRP and P
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of POP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads POP7 as an antibody target. Whether an autoantibody or antibody against POP7 could matter depends on whether native POP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
POP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label POP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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