Seroatlas · Human Serome Atlas

RPP38

Ribonuclease P protein subunit p38

Also known as: RPP38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78345
Gene: RPP38
Ensembl: ENSG00000152464
Chromosome: 10
Canonical length: 283 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in fibrillar center. Part of multimeric ribonuclease P complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>P78345|RPP38
     1  MAAAPQAPGR GSLRKTRPLV VKTSLNNPYI IRWSALESED MHFILQTLED RLKAIGLQKI
    61  EDKKKKNKTP FLKKESREKC SIAVDISENL KEKKTDAKQQ VSGWTPAHVR KQLAIGVNEV
   121  TRALERRELL LVLVCKSVKP AMITSHLIQL SLSRSVPACQ VPRLSERIAP VIGLKCVLAL
   181  AFKKNTTDFV DEVRAIIPRV PSLSVPWLQD RIEDSGENLE TEPLESQDRE LLDTSFEDLS
   241  KPKRKLADGR QASVTLQPLK IKKLIPNPNK IRKPPKSKKA TPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPP38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

testis: 46 nTPM
cerebellum: 21 nTPM
lymph node: 19 nTPM
liver: 19 nTPM
breast: 19 nTPM
skeletal muscle: 18 nTPM

Single-cell type

early spermatids: 551 nCPM
late primary spermatocytes: 416 nCPM
late spermatids: 306 nCPM
adipocytes: 188 nCPM
respiratory ciliated cells: 130 nCPM
fallopian tube ciliated cells: 98 nCPM

Immune cell

naive B-cell: 66 nTPM
memory CD8 T-cell: 61 nTPM
memory B-cell: 59 nTPM
naive CD4 T-cell: 57 nTPM
naive CD8 T-cell: 53 nTPM
plasmacytoid DC: 53 nTPM

Brain region

choroid plexus: 27 nTPM
cerebellum: 21 nTPM
white matter: 17 nTPM
cerebral cortex: 17 nTPM
hypothalamus: 16 nTPM
hippocampal formation: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.22
DepMap mean gene effect: -0.95
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ribonuclease P RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ribosomal protein eL8/eL30/eS12/Gadd45
Ribosomal protein eL30-like superfamily
Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Ribonuclease P protein subunit Rpp38

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPP38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPP38 as an antibody target. Whether an autoantibody or antibody against RPP38 could matter depends on whether native RPP38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPP38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPP38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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