Seroatlas · Human Serome Atlas

TMEM33

Transmembrane protein 33

Also known as: FLJ10525, Pom33, TMM33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57088
Gene: TMEM33
Ensembl: ENSG00000109133
Chromosome: 4
Canonical length: 247 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>P57088|TMEM33
     1  MADTTPNGPQ GAGAVQFMMT NKLDTAMWLS RLFTVYCSAL FVLPLLGLHE AASFYQRALL
    61  ANALTSALRL HQRLPHFQLS RAFLAQALLE DSCHYLLYSL IFVNSYPVTM SIFPVLLFSL
   121  LHAATYTKKV LDARGSNSLP LLRSVLDKLS ANQQNILKFI ACNEIFLMPA TVFMLFSGQG
   181  SLLQPFIYYR FLTLRYSSRR NPYCRTLFNE LRIVVEHIIM KPACPLFVRR LCLQSIAFIS
   241  RLAPTVP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

liver: 37 nTPM
parathyroid gland: 28 nTPM
epididymis: 24 nTPM
kidney: 23 nTPM
thyroid gland: 22 nTPM
urinary bladder: 20 nTPM

Single-cell type

neutrophils: 246 nCPM
syncytiotrophoblasts: 208 nCPM
esophageal apical cells: 136 nCPM
retinal pigment epithelial cells: 128 nCPM
kupffer cells: 116 nCPM
monocyte progenitors: 112 nCPM

Immune cell

neutrophil: 43 nTPM
basophil: 41 nTPM
non-classical monocyte: 35 nTPM
classical monocyte: 32 nTPM
intermediate monocyte: 31 nTPM
myeloid DC: 23 nTPM

Brain region

white matter: 65 nTPM
choroid plexus: 59 nTPM
medulla oblongata: 57 nTPM
spinal cord: 54 nTPM
midbrain: 54 nTPM
pons: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0.01
gnomAD missense Z: 0.79
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

TMEM33/Pom33 family
PER33/POM33 transmembrane regulator
Transmembrane protein 33/Nucleoporin POM33

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM33 as an antibody target. Whether an autoantibody or antibody against TMEM33 could matter depends on whether native TMEM33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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