Seroatlas · Human Serome Atlas

ENDOD1

Endonuclease domain-containing 1 protein

Also known as: ENDD1_HUMAN, KIAA0830

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94919
Gene
ENDOD1
Ensembl
ENSG00000149218
Chromosome
11
Canonical length
500 aa
Protein class
Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Nuclear membrane
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to enable endonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be involved in innate immune response. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>O94919|ENDOD1
     1  MGTARWLALG SLFALAGLLE GRLVGEEEAG FGECDKFFYA GTPPAGLAAD SHVKICQRAE
    61  GAERFATLYS TRDRIPVYSA FRAPRPAPGG AEQRWLVEPQ IDDPNSNLEE AINEAEAITS
   121  VNSLGSKQAL NTDYLDSDYQ RGQLYPFSLS SDVQVATFTL TNSAPMTQSF QERWYVNLHS
   181  LMDRALTPQC GSGEDLYILT GTVPSDYRVK DKVAVPEFVW LAACCAVPGG GWAMGFVKHT
   241  RDSDIIEDVM VKDLQKLLPF NPQLFQNNCG ETEQDTEKMK KILEVVNQIQ DEERMVQSQK
   301  SSSPLSSTRS KRSTLLPPEA SEGSSSFLGK LMGFIATPFI KLFQLIYYLV VAILKNIVYF
   361  LWCVTKQVIN GIESCLYRLG SATISYFMAI GEELVSIPWK VLKVVAKVIR ALLRILCCLL
   421  KAICRVLSIP VRVLVDVATF PVYTMGAIPI VCKDIALGLG GTVSLLFDTA FGTLGGLFQV
   481  VFSVCKRIGY KVTFDNSGEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENDOD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 60 nTPM
  • spinal cord: 50 nTPM
  • skeletal muscle: 49 nTPM
  • prostate: 45 nTPM
  • midbrain: 40 nTPM
  • rectum: 36 nTPM

Single-cell type

  • platelets: 695 nCPM
  • schwann cells: 162 nCPM
  • oligodendrocytes: 159 nCPM
  • lymphatic endothelial cells: 95 nCPM
  • granulosa cells: 93 nCPM
  • vascular smooth muscle cells: 87 nCPM

Immune cell

  • memory B-cell: 4.7 nTPM
  • naive B-cell: 4.7 nTPM
  • total PBMC: 4.2 nTPM
  • non-classical monocyte: 3.9 nTPM
  • gdT-cell: 3.6 nTPM
  • MAIT T-cell: 3.4 nTPM

Brain region

  • white matter: 151 nTPM
  • pons: 110 nTPM
  • basal ganglia: 109 nTPM
  • midbrain: 98 nTPM
  • medulla oblongata: 97 nTPM
  • cerebellum: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0
gnomAD missense Z
0.01
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENDOD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENDOD1 as an antibody target. Whether an autoantibody or antibody against ENDOD1 could matter depends on whether native ENDOD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENDOD1 is annotated as secreted, so native ENDOD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ENDOD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ENDOD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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