WWE domain superfamily
IPR037197
Definition
The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor PMID:16271883. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins PMID:11343911. Structurally, the WWE domain has a β(2)-α-β(4) fold with antiparallel folded β-sheet (half-barrel).
11 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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